Charwat-Resl Silvia, Yarragudi Rajashri, Heimbach Moritz, Leitner Karoline, Leutner Michael, Gamper Jutta, Giurgea Georgiana-Aura, Mueller Markus, Koppensteiner Renate, Gschwandtner Michael E, Kautzky-Willer Alexandra, Schlager Oliver
1 Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
2 Cardiology and Intensive Care Medicine, Department of Medicine II, Klinikum Wels-Grieskirchen, Wels, Austria.
Diab Vasc Dis Res. 2017 May;14(3):214-220. doi: 10.1177/1479164116683148. Epub 2017 Jan 23.
In the long term, diabetes mellitus is potentially associated with the occurrence of microvascular damage. This study sought to assess whether a history of prior gestational diabetes mellitus is associated with long-term effects on the women's microcirculation.
Within the scope of a long-term follow-up of the 'Viennese Post-Gestational Diabetes Project', women with prior gestational diabetes mellitus as well as women with previous pregnancy but with no history of gestational diabetes mellitus (controls) were enrolled in this cross-sectional study. Microvascular function was assessed by post-occlusive reactive hyperaemia using laser Doppler fluxmetry. Baseline perfusion, biological zero, peak perfusion, time to peak and recovery time were recorded and compared between both groups.
Microvascular function was assessed in 55 women with prior gestational diabetes mellitus (46.1 ± 4.6 years) and 32 women with previous pregnancy but without prior gestational diabetes mellitus (42.9 ± 5.3 years). The mean period of time between delivery and the assessment of microvascular function was 16.2 ± 5.2 years in women with prior gestational diabetes mellitus group and 14.2 ± 4.8 years in controls. Regarding microvascular function, baseline perfusion, biological zero, peak perfusion, time to peak and recovery time did not differ between women with prior gestational diabetes mellitus and controls (all p > 0.05).
In the long term, microvascular function appears not to be impaired in women with prior gestational diabetes mellitus.
从长远来看，糖尿病可能与微血管损伤的发生有关。本研究旨在评估既往妊娠糖尿病史是否与对女性微循环的长期影响有关。
在“维也纳妊娠后糖尿病项目”的长期随访范围内，将既往有妊娠糖尿病的女性以及既往有过妊娠但无妊娠糖尿病史的女性（对照组）纳入本横断面研究。使用激光多普勒血流仪通过闭塞后反应性充血评估微血管功能。记录并比较两组的基线灌注、生物学零值、峰值灌注、达到峰值的时间和恢复时间。
对55名既往有妊娠糖尿病的女性（46.1±4.6岁）和32名既往有过妊娠但无妊娠糖尿病的女性（42.9±5.3岁）进行了微血管功能评估。既往有妊娠糖尿病的女性组从分娩到微血管功能评估的平均时间为16.2±5.2年，对照组为14.2±4.8年。关于微血管功能，既往有妊娠糖尿病的女性和对照组之间的基线灌注、生物学零值、峰值灌注、达到峰值的时间和恢复时间没有差异（所有p>0.05）。
从长远来看，既往有妊娠糖尿病的女性微血管功能似乎未受损。
