Santagostino A, Giagnoni G, Reina R, Spadaro C, Ferri S
Arch Toxicol Suppl. 1978(1):331-3. doi: 10.1007/978-3-642-66896-8_70.
Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as mumoles of p-hydroxyphenylpyruvate/100 mg/h. With chronic administration, a tolerance develops to this enzymatic effect. TAT induction is not evident in pregnant rats, given the narcotic, in which enzyme levels are already initially high. After delivery TAT returns to normal levels and it is possible to show both induction and tolerance developing to morphine. Enzyme activity in fetal livers is much lower than that of adult animals: after maternal administration of morphine only a modest TAT increase is seen which is not, however, statistically significant. TAT activity is fully evident in livers of offspring, with much higher mean levels in newborn rats from morphine-treated animals, as a possible consequence of morphine deprivation. In this latter group of newborn rats narcotic administration causes TAT activity to return to levels as high as those of naive animals. On the other hand, morphine administration to the prole of naive rats results in an induction of liver TAT.
给大鼠急性注射吗啡（20毫克/千克/皮下注射）会导致肝脏酪氨酸转氨酶（TAT）升高，以对羟基苯丙酮酸的微摩尔数/100毫克/小时表示。长期给药后，会对这种酶促作用产生耐受性。给怀孕大鼠注射这种麻醉剂后，TAT诱导不明显，因为其酶水平一开始就很高。分娩后，TAT恢复到正常水平，并且可以显示出对吗啡的诱导和耐受性发展。胎儿肝脏中的酶活性远低于成年动物：母体注射吗啡后，仅观察到TAT有适度增加，但无统计学意义。TAT活性在后代肝脏中完全显现，来自吗啡处理动物的新生大鼠平均水平要高得多，这可能是吗啡剥夺的结果。在这组新生大鼠中，给予麻醉剂会使TAT活性恢复到与未处理动物一样高的水平。另一方面，给未处理大鼠的后代注射吗啡会导致肝脏TAT诱导。
