酰胺配体控制的芳基硼酸对单取代简单芳烃的高对位选择性芳基化反应。
Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids.
机构信息
State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, China.
出版信息
J Am Chem Soc. 2017 Feb 8;139(5):1786-1789. doi: 10.1021/jacs.6b12907. Epub 2017 Jan 26.
Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and found to be critical for the selectivity control in current arylations.
钯催化的单取代简单芳基与芳基硼酸的高对位选择性芳基化反应，生成广泛存在的联芳烃。受报道的选择性氧化偶联中必需酰胺导向基团的启发，酰胺配体，特别是 DMF，被设计并发现对当前芳基化反应的选择性控制至关重要。
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