用于近红外可视化皮肤伤口的便携式成像仪的设计。
Design of a portable imager for near-infrared visualization of cutaneous wounds.
机构信息
University of Texas at Arlington, Department of Electrical Engineering, P.O. Box 19016, Arlington, Texas 76019, United States.
University of Texas at Arlington, Department of Bioengineering, P.O. Box 19138, Arlington, Texas 76019, United States.
出版信息
J Biomed Opt. 2017 Jan 1;22(1):16010. doi: 10.1117/1.JBO.22.1.016010.
A portable imager developed for real-time imaging of cutaneous wounds in research settings is described. The imager consists of a high-resolution near-infrared CCD camera capable of detecting both bioluminescence and fluorescence illuminated by an LED ring with a rotatable filter wheel. All external components are integrated into a compact camera attachment. The device is demonstrated to have competitive performance with a commercial animal imaging enclosure box setup in beam uniformity and sensitivity. Specifically, the device was used to visualize the bioluminescence associated with increased reactive oxygen species activity during the wound healing process in a cutaneous wound inflammation model. In addition, this device was employed to observe the fluorescence associated with the activity of matrix metalloproteinases in a mouse lipopolysaccharide-induced infection model. Our results support the use of the portable imager design as a noninvasive and real-time imaging tool to assess the extent of wound inflammation and infection.
一种用于研究环境下皮肤伤口实时成像的便携式成像仪得到了描述。该成像仪由一个高分辨率近红外 CCD 相机组成，该相机能够检测到由带有可旋转滤光轮的 LED 环照亮的生物发光和荧光。所有外部组件都集成到一个紧凑的相机附件中。该设备在光束均匀性和灵敏度方面与商业动物成像盒设备具有竞争性能。具体来说，该设备用于可视化在皮肤伤口炎症模型中，与活性氧物种增加相关的生物发光。此外，该设备还用于观察与脂多糖诱导的感染模型中基质金属蛋白酶活性相关的荧光。我们的结果支持使用便携式成像仪设计作为一种非侵入性和实时成像工具，以评估伤口炎症和感染的程度。
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