Martínez-Jiménez David, Garner Bridget, Coutermarsh-Ott Sheryl, Burrell Caitlin, Clark Sabrina, Nabity Mary, Díaz-Delgado Josué, Rodrigues-Hoffmann Aline, Zaks Karen, Proença Laila, Divers Stephen, Saba Corey, Cazzini Paola
Loving Hands Animal Clinic (Martínez-Jiménez), Alpharetta, GA.
Departments of Pathology (Cazzini, Coutermarsh-Ott, Garner) and Small Animal Medicine and Surgery (Proença, Divers, Saba), College of Veterinary Medicine, University of Georgia, Athens, GA.
J Vet Diagn Invest. 2017 Mar;29(2):217-223. doi: 10.1177/1040638716687603. Epub 2017 Jan 24.
Neoplasia is usually encountered in the African pygmy hedgehog at a mean age of 3.5 y, and malignancy is common. Myelogenous leukemias are rarely reported in hedgehogs. We describe 3 cases of eosinophilic leukemia in adult, middle-aged (mean age: 2.3 y) hedgehogs, for which prognosis appears grave. In 1 case, attempted treatment was unsuccessful, and in all 3 cases, the disease course was rapid and all died soon after diagnosis. Blood smear evaluation, along with complete blood count, was critical in making the diagnosis in all cases. Luna stain was validated and used to better visualize eosinophils in cytologic and histologic sections. Electron microscopy confirmed the presence of specific granules in hedgehog eosinophils.
肿瘤形成在非洲侏儒刺猬中通常在平均3.5岁时出现，且恶性肿瘤很常见。刺猬中髓细胞性白血病鲜有报道。我们描述了3例成年、中年（平均年龄：2.3岁）刺猬的嗜酸性粒细胞白血病病例，其预后似乎很严峻。在1例病例中，尝试治疗未成功，在所有3例病例中，病程进展迅速，均在诊断后不久死亡。血液涂片评估以及全血细胞计数在所有病例的诊断中都至关重要。Luna染色经验证后用于在细胞学和组织学切片中更好地观察嗜酸性粒细胞。电子显微镜证实刺猬嗜酸性粒细胞中存在特异性颗粒。
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