犬致密型和滤泡致密型甲状腺癌中增殖、血管生成及分化相关标志物

Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs.

作者信息

Pessina P, Castillo V A, César D, Sartore I, Meikle A

机构信息

Laboratorio de Técnicas Nucleares, Facultad de Veterinaria, Universidad de la República, Lasplaces 1550, Montevideo, Uruguay.

Cat. Clin. Méd. Peq. An. and U. Endocrinología, Escuela Medicina Veterinaria, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires. Av. Chorroarín 280, C. Autónoma de Buenos Aires, Argentina.

出版信息

Open Vet J. 2016;6(3):247-254. doi: 10.4314/ovj.v6i3.15. Epub 2016 Dec 19.

DOI:10.4314/ovj.v6i3.15

PMID:28116249

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5223283/

Abstract

Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands ( < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells ( < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups ( < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.

摘要

在健康犬甲状腺（n = 8）、滤泡致密型甲状腺癌（n = 8）和致密型甲状腺癌（n = 8）中评估免疫组化标志物（IGF-1、IGF-1R、VEGF、FGF-2、RARα和RXR）。致密型癌的成纤维细胞和内皮细胞中IGF-1、IGF-1R和VEGF表达高于健康腺体（P < 0.05）。与滤泡致密型癌相比，致密型癌的成纤维细胞中IGF-1R表达更高，内皮细胞中FGF-2表达更高（P < 0.05）。致密型癌的内皮细胞中RARα表达高于其他组（P < 0.05）。与健康腺体相比，致密型癌的内皮细胞和/或成纤维细胞而非滤泡细胞中这些增殖和血管生成相关因子的上调支持了基质细胞在癌症进展中的相关性。