硫酸胍丁胺对面神经损伤的影响。
Effects of agmatine sulphate on facial nerve injuries.
作者信息
Surmelioglu O, Sencar L, Ozdemir S, Tarkan O, Dagkiran M, Surmelioglu N, Tuncer U, Polat S
机构信息
Department of Otorhinolaryngology,Cukurova University,Adana,Turkey.
Department of Histology,Faculty of Medicine,Cukurova University,Adana,Turkey.
出版信息
J Laryngol Otol. 2017 Mar;131(3):221-226. doi: 10.1017/S0022215117000147. Epub 2017 Jan 26.
OBJECTIVE
To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.
METHODS
The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.
RESULTS
Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).
CONCLUSION
Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.
目的
运用电子显微镜和光学显微镜评估硫酸胍丁胺对面神经损伤后神经再生的影响。
方法
选取30只雄性Wistar白化大鼠进行研究，分为：对照组、假处理组、研究对照组、吻合组以及吻合加硫酸胍丁胺治疗组。解剖面神经下颌支，取一块组织进行组织学和电子显微镜检查。
结果
吻合组的神经再生情况优于研究对照组。然而，硫酸胍丁胺治疗组的神经再生效果最佳。胍丁胺组与其他组在轴突中位数数量（p < 0.004）和直径（p < 0.004）方面存在显著差异。
结论
外伤性面瘫吻合术后采用硫酸胍丁胺治疗可能会促进神经再生。
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