Sun Guangyu, Larsen Christopher N, Baumgarth Nicole, Klem Edward B, Scheuermann Richard H
Vecna Technologies, Inc., Greenbelt, Maryland, United States of America.
Center for Comparative Medicine and the Department of Pathology, Microbiology & Immunology, University of California, Davis, Davis, California, United States of America.
PLoS One. 2017 Jan 26;12(1):e0170462. doi: 10.1371/journal.pone.0170462. eCollection 2017.
The rapid spread of Zika virus (ZIKV) has caused much concern in the global health community, due in part to a link to fetal microcephaly and other neurological illnesses. While an increasing amount of ZIKV genomic sequence data is being generated, an understanding of the virus molecular biology is still greatly lacking. A significant step towards establishing ZIKV proteomics would be the compilation of all proteins produced by the virus, and the resultant virus genotypes. Here we report for the first time such data, using new computational methods for the annotation of mature peptide proteins, genotypes, and recombination events for all ZIKV genomes. The data is made publicly available through the Virus Pathogen Resource at www.viprbrc.org.
寨卡病毒（ZIKV）的迅速传播引起了全球卫生界的广泛关注，部分原因是它与胎儿小头畸形及其他神经疾病有关。尽管越来越多的寨卡病毒基因组序列数据不断产生，但对该病毒分子生物学的了解仍十分匮乏。迈向建立寨卡病毒蛋白质组学的重要一步将是汇编该病毒产生的所有蛋白质以及由此产生的病毒基因型。在此，我们首次报告此类数据，运用新的计算方法对所有寨卡病毒基因组的成熟肽蛋白质、基因型及重组事件进行注释。这些数据通过www.viprbrc.org的病毒病原体资源网站公开提供。
