通过超声评估的严重颈动脉狭窄与中风后血管性认知障碍相关。
Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment.
作者信息
Li Xuefeng, Ma Xiangling, Lin Jing, He Xiangqin, Tian Feng, Kong Dongmei
机构信息
Department of Ultrasonography Jining No.1 People's Hospital Jining Shandong China.
Health Supervision Institute Zoucheng Municipal Health Bureau Zoucheng Shandong China.
出版信息
Brain Behav. 2016 Nov 22;7(1):e00606. doi: 10.1002/brb3.606. eCollection 2017 Jan.
BACKGROUND
Acute ischemic stroke has been recognized as one key cause of vascular cognitive impairment (VCI). The purpose of this study was to evaluate the correlation between carotid artery stenosis and post VCI in acute ischemic stroke patients.
METHODS
In this study, B-mode ultrasound was applied to measure the degree of carotid artery stenosis. After 1 year, the stroke patients' cognitive function was assessed by the mini-mental state examination (MMSE) score. The relationship between the VCI and degree of carotid artery stenosis was evaluated by multivariate regression analysis.
RESULTS
VCI was observed in 136 (37.2%) of the 365 participants. High degree of carotid artery stenosis was significantly correlated with VCI ( < .01), and this correlation remained unchanged even adjustment for age, gender, education level, stroke features, and vascular risk factors.
CONCLUSIONS
These findings indicate that high-grade stenosis of carotid artery is positively correlated with post stroke VCI in patients with acute ischemic stroke. The evaluation of 1 year post stroke cognitive function may be a potential tool for screening stroke patients at risk of VCI.
背景
急性缺血性卒中已被公认为是血管性认知障碍（VCI）的一个关键病因。本研究旨在评估急性缺血性卒中患者颈动脉狭窄与卒中后VCI之间的相关性。
方法
在本研究中，应用B型超声测量颈动脉狭窄程度。1年后，通过简易精神状态检查表（MMSE）评分评估卒中患者的认知功能。通过多因素回归分析评估VCI与颈动脉狭窄程度之间的关系。
结果
365名参与者中有136名（37.2%）出现VCI。颈动脉高度狭窄与VCI显著相关（P<0.01），即使对年龄、性别、教育水平、卒中特征和血管危险因素进行校正，这种相关性仍未改变。
结论
这些发现表明，急性缺血性卒中患者颈动脉高度狭窄与卒中后VCI呈正相关。卒中后1年认知功能评估可能是筛查有VCI风险的卒中患者的一种潜在工具。
Zotero 插件