Silva Jonas G, Boareto Ana C, Schreiber Anne K, Redivo Daiany D B, Gambeta Eder, Vergara Fernanda, Morais Helen, Zanoveli Janaína M, Dalsenter Paulo R
Department of Chemistry and Biology, Federal Technological University of Paraná, Curitiba, Paraná 81280-340, Brazil; Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
Department of Pharmacology, Federal University of Paraná, Curitiba, Paraná 81540-990 Brazil.
Neurosci Lett. 2017 Feb 22;641:94-100. doi: 10.1016/j.neulet.2017.01.053. Epub 2017 Jan 24.
Chlorpyrifos is a pesticide, member of the organophosphate class, widely used in several countries to manage insect pests on many agricultural crops. Currently, chlorpyrifos health risks are being reevaluated due to possible adverse effects, especially on the central nervous system. The aim of this study was to investigate the possible action of this pesticide on the behaviors related to anxiety and depression of offspring rats exposed during pregnancy. Wistar rats were treated orally with chlorpyrifos (0.01, 0.1, 1 and 10mg/kg/day) on gestational days 14-20. Male offspring behavior was evaluated on post-natal days 21 and 70 by the elevated plus-maze test, open field test and forced swimming test. The results demonstrated that exposure to 0.1, 1 or 10mg/kg/day of chlorpyrifos could induce anxiogenic-like, but not depressive-like behavior at post-natal day 21, without causing fetal toxicity. This effect was reversed on post-natal day 70.
毒死蜱是一种有机磷酸酯类杀虫剂，在多个国家被广泛用于防治多种农作物上的害虫。目前，由于可能存在的不良影响，尤其是对中枢神经系统的影响，毒死蜱对健康的风险正在重新评估。本研究的目的是调查这种农药对孕期接触过它的子代大鼠焦虑和抑郁相关行为可能产生的作用。在妊娠第14至20天，对Wistar大鼠经口给予毒死蜱（0.01、0.1、1和10mg/kg/天）。在出生后第21天和70天，通过高架十字迷宫试验、旷场试验和强迫游泳试验对子代雄性大鼠的行为进行评估。结果表明，在出生后第21天，接触0.1、1或10mg/kg/天的毒死蜱可诱发类似焦虑的行为，但不会诱发类似抑郁的行为，且不会导致胎儿毒性。这种效应在出生后第70天有所逆转。
