一种用于测定氯普噻吨顺式/反式异构含量的核磁共振（NMR）方法。
A nuclear magnetic resonance (NMR) method for the determination of the cis/trans isomeric content of chlorprothixene.
作者信息
Rosler K H, Wright J, Fox K M, Waters R M, Callery P S
机构信息
Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
出版信息
Pharm Res. 1989 Aug;6(8):706-8. doi: 10.1023/a:1015942623581.
Proton NMR spectroscopy was applied to the assignment of the isomeric identity of commercially available chlorprothixene. Nuclear Overhauser effect studies confirmed that the clinically useful isomer is the cis (Z) configuration. An NMR method for determining the isomeric content of chlorprothixene was developed based on integration of the ratio of areas of signal strength of the cis-N-methyl in comparison to the trans-N-methyl resonances.
质子核磁共振光谱法被用于确定市售氯丙嗪异构体的身份。核Overhauser效应研究证实，临床上有用的异构体是顺式（Z）构型。基于顺式N-甲基与反式N-甲基共振信号强度面积比的积分，开发了一种测定氯丙嗪异构体含量的核磁共振方法。
Zotero 插件