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斜视手术后发生手术性坏死性巩膜炎,局部应用N-乙酰半胱氨酸成功治疗一名患有先天性眼外肌纤维化和瓦拉迪·帕普综合征的儿童

Surgically Induced Necrotizing Scleritis Following Strabismus Surgery Treated Successfully with Topical N-acetylcysteine in a Child with Congenital Fibrosis of Extraocular Muscles and Varadi Papp Syndrome.

作者信息

Rajamani Muralidhar, Nagasubramanian Vidhya, Ayyavoo Ahila, Raghupathy Palany, Dandapani Ramamurthy

机构信息

b Department of Pediatric Ophthalmology and Strabismus , The Eye Foundation , Coimbatore , India.

a Department of Paediatric Endocrinology and Diabetes , G. Kuppuswamy Naidu Memorial Hospital , Coimbatore , India.

出版信息

Strabismus. 2017 Mar;25(1):39-42. doi: 10.1080/09273972.2016.1277768. Epub 2017 Jan 31.

Abstract

INTRODUCTION

Surgically induced necrotizing scleritis (SINS) is a rare but serious disorder that can develop many years after strabismus surgery. It is generally treated with high-dose steroids or immunosuppression.

CASE REPORT

We describe a patient with Varadi Papp syndrome and congenital fibrosis of the extraocular muscles, who developed surgically induced necrotizing scleritis a month after strabismus surgery and was successfully managed by oral vitamin C and topical N-acetylcysteine 10%.

DISCUSSION

While SINS is conventionally treated with steroids/immunosuppression, a conservative approach may be tried in milder cases. The role of topical N-acetylcysteine in managing this complication needs to be explored.

摘要

引言

手术诱发的坏死性巩膜炎(SINS)是一种罕见但严重的疾病,可在斜视手术后数年发生。通常采用大剂量类固醇或免疫抑制治疗。

病例报告

我们描述了一名患有瓦拉迪 - 帕普综合征和眼外肌先天性纤维化的患者,该患者在斜视手术后一个月发生了手术诱发的坏死性巩膜炎,并通过口服维生素C和局部使用10%的N - 乙酰半胱氨酸成功治疗。

讨论

虽然传统上SINS采用类固醇/免疫抑制治疗,但在较轻的病例中可尝试保守方法。局部使用N - 乙酰半胱氨酸在处理这种并发症中的作用需要进一步探索。

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