转移性非典型性和间变性脑膜瘤：病例系列及文献综述
Metastatic Atypical and Anaplastic Meningioma: A Case Series and Review of the Literature.
作者信息
Kessler Remi A, Garzon-Muvdi Tomas, Yang Wuyang, Weingart Jon, Olivi Alessandro, Huang Judy, Brem Henry, Lim Michael
机构信息
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Department of Neurosurgery, Policlinico Universitario A. Gemelli, Rome, Italy.
出版信息
World Neurosurg. 2017 May;101:47-56. doi: 10.1016/j.wneu.2017.01.070. Epub 2017 Jan 29.
BACKGROUND
Atypical (World Health Organization grade II) and anaplastic (World Health Organization grade III) meningiomas are rare, accounting for less than 5% of all meningiomas. Histologic grading has a significant impact on prognosis, risk of recurrence, and the need for adjuvant radiation or chemotherapy. Extracranial metastases are even more infrequent and occur in 0.1% of all cases.
METHODS
Retrospective chart review of 168 patients with diagnosis of WHO grade II and III meningiomas was performed. Six patients with histologically confirmed metastatic disease were identified.
RESULTS
We discuss the clinical, radiologic, and histopathologic clinical course of 6 patients with metastasis to the lung, liver, and spine from all patients with atypical or anaplastic meningioma treated at Johns Hopkins Hospital from 1993 to 2014.
CONCLUSIONS
We reviewed the literature pertaining to this phenomenon and subsequently assessed the clinical benefits of adjuvant chemotherapeutic agents in patients with meningioma with metastatic disease.
背景
非典型（世界卫生组织二级）和间变性（世界卫生组织三级）脑膜瘤较为罕见，占所有脑膜瘤的比例不到5%。组织学分级对预后、复发风险以及辅助放疗或化疗的需求有重大影响。颅外转移更为少见，在所有病例中发生率为0.1%。
方法
对168例诊断为世界卫生组织二级和三级脑膜瘤的患者进行回顾性病历审查。确定了6例组织学确诊为转移性疾病的患者。
结果
我们讨论了1993年至2014年在约翰霍普金斯医院接受治疗的所有非典型或间变性脑膜瘤患者中6例发生肺、肝和脊柱转移患者的临床、放射学和组织病理学临床过程。
结论
我们回顾了有关这一现象的文献，随后评估了辅助化疗药物对患有转移性疾病的脑膜瘤患者的临床益处。
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