Sharma Aditya Kumar, Dhasmana Neha, Dubey Neha, Kumar Nishant, Gangwal Aakriti, Gupta Meetu, Singh Yogendra
CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi, 110007 India.
Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001 India.
Indian J Microbiol. 2017 Mar;57(1):1-10. doi: 10.1007/s12088-016-0625-1. Epub 2016 Nov 5.
Virulence is described as an ability of an organism to infect the host and cause a disease. Virulence factors are the molecules that assist the bacterium colonize the host at the cellular level. These factors are either secretory, membrane associated or cytosolic in nature. The cytosolic factors facilitate the bacterium to undergo quick adaptive-metabolic, physiological and morphological shifts. The membrane associated virulence factors aid the bacterium in adhesion and evasion of the host cell. The secretory factors are important components of bacterial armoury which help the bacterium wade through the innate and adaptive immune response mounted within the host. In extracellular pathogens, the secretory virulence factors act synergistically to kill the host cells. In this review, we revisit the role of some of the secreted virulence factors of two human pathogens: -an intracellular pathogen and -an extracellular pathogen. The advances in research on the role of secretory factors of these pathogens during infection are discussed.
毒力被描述为生物体感染宿主并引发疾病的能力。毒力因子是在细胞水平上协助细菌在宿主体内定殖的分子。这些因子本质上要么是分泌性的、与膜相关的,要么是胞质的。胞质因子促进细菌经历快速的适应性代谢、生理和形态转变。与膜相关的毒力因子帮助细菌黏附并逃避宿主细胞。分泌因子是细菌武器库的重要组成部分,有助于细菌抵御宿主内的固有免疫和适应性免疫反应。在细胞外病原体中,分泌性毒力因子协同作用杀死宿主细胞。在本综述中,我们重新审视两种人类病原体(一种细胞内病原体和一种细胞外病原体)的一些分泌性毒力因子的作用。讨论了这些病原体感染期间分泌因子作用的研究进展。