Yasuda Michiko T, Sakakibara Hiroyuki, Shimoi Kayoko
School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526 Japan.
Faculty of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai-nishi, Miyazaki, 889-2192 Japan.
Genes Environ. 2017 Feb 1;39:10. doi: 10.1186/s41021-016-0071-7. eCollection 2017.
Breast cancer is one of the most commonly diagnosed female cancers and a leading cause of cancer-related death in women. Multiple factors are responsible for breast cancer and heritable factors have received much attention. DNA damage in breast cancer is induced by prolonged exposure to estrogens, such as 17β-estradiol, daily social/psychological stressors, and environmental chemicals such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs). DNA damage induced by estrogen and stress is an important factor in the pathogenesis and development of breast cancer and is now recognized as a critical provision for chemoprevention of breast cancer. In this review, we summarize the relationships between estrogen- and stress-induced DNA damage with regard to the pathogenesis and development of breast cancer. We also discuss recent investigations into chemoprevention using dietary flavonoids such as quercetin and isoflavones.
乳腺癌是女性中最常被诊断出的癌症之一，也是女性癌症相关死亡的主要原因。乳腺癌由多种因素引起，其中遗传因素备受关注。乳腺癌中的DNA损伤是由长期暴露于雌激素（如17β-雌二醇）、日常社会/心理压力源以及环境化学物质（如多环芳烃（PAHs）和杂环胺（HCAs））所诱发的。雌激素和压力诱导的DNA损伤是乳腺癌发病机制和发展过程中的一个重要因素，目前被认为是乳腺癌化学预防的关键条件。在本综述中，我们总结了雌激素和压力诱导的DNA损伤与乳腺癌发病机制和发展之间的关系。我们还讨论了近期关于使用膳食黄酮类化合物（如槲皮素和异黄酮）进行化学预防的研究。
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