Bedreag Ovidiu H, Papurica Marius, Rogobete Alexandru F, Sandesc Dorel, Dumache Raluca, Cradigati Carmen A, Sarandan Mirela, Bratu Lavinia M, Popovici Sonia E, Sima Laurentiu V
Clin Lab. 2016 Aug 1;62(8):1397-1403. doi: 10.7754/Clin.Lab.2016.160121.
The multiple-traumatic critical patient presents a variety of pathophysiological, cellular, and molecular dysfunctions. One of the most important is represented by mitochondrial damage which afterwards is responsible for the augmentation and worsening of a series of pathologies that lead to the worsening of the clinical status of the patient. The severe inflammatory response, sepsis, and the redox imbalance are other pathologies that together with the multiple traumas are responsible for the mitochondrial dysfunctions. As an overview, we can say that both the mitochondrial damage as well as the clinical statuses of those patients are responsible for an increase in the chances of multiple organ dysfunction syndrome and death of critical patients with multiple trauma from the Intensive Care Units (ICU). In this paper we wish to summarize the microRNAs that can be used as biomarkers for evaluation and monitoring of the mitochondrial activity in critical patients with multiple traumas.
For the paper, literature available in the international databases PubMed and Scopus until the year 2015 has been consulted. The key words used for the article search were "mitochondrial damage", "microRNAs biomarkers", and "critically ill polytrauma patients".
As a result of the research based on the key words presented above, we found 234 papers. From those, after rigorous analysis 64 were selected as being in conformity with the needs of this paper.
The critical polytrauma patient needs a specific evaluation and monitoring due to the complexity of the dysfunctions that appear at the cellular level. The use of microRNAs as biomarkers for the mitochondrial damage can be of real use for intensive care medicine. Nevertheless, more studies are required in order to determine a larger panel of microRNAs which can have an impact on mitochondrial damage.
多发伤重症患者存在多种病理生理、细胞和分子功能障碍。其中最重要的一种表现为线粒体损伤，其随后会导致一系列病理状况的加重和恶化，进而使患者的临床状况恶化。严重炎症反应、脓毒症和氧化还原失衡是其他与多发伤共同导致线粒体功能障碍的病理状况。总体而言，我们可以说线粒体损伤以及这些患者的临床状况都会增加多发伤重症患者发生多器官功能障碍综合征以及在重症监护病房（ICU）死亡的几率。在本文中，我们希望总结可作为评估和监测多发伤重症患者线粒体活性生物标志物的微小RNA。
对于本文，查阅了截至2015年国际数据库PubMed和Scopus中可用的文献。用于文章检索的关键词为“线粒体损伤”“微小RNA生物标志物”和“重症多发伤患者”。
基于上述关键词进行研究，我们找到了234篇论文。经过严格分析，从中选出64篇符合本文需求的论文。
由于细胞水平出现的功能障碍的复杂性，重症多发伤患者需要进行特定的评估和监测。将微小RNA用作线粒体损伤的生物标志物对重症医学可能具有实际用途。然而，为了确定更多可能对线粒体损伤有影响的微小RNA，还需要更多的研究。
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