Woo Yu Ri, Hwang Sewon, Jeong Seo Won, Cho Dae Ho, Park Hyun Jeong
Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.
Institute of Clinical Medical Research, Yeouido St. Mary's Hostpital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.
Int J Mol Sci. 2017 Feb 3;18(2):316. doi: 10.3390/ijms18020316.
Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.
已知红系分化调节因子1（Erdr1）通过调节免疫系统参与多种皮肤疾病（如银屑病和酒渣鼻）的炎症过程。然而，Erdr1在各种脱发疾病中的作用仍不清楚。本研究的目的是探讨Erdr1在脱发中的假定作用。收集了21例脱发疾病患者和5例对照受试者的皮肤样本，以评估其Erdr1的表达水平。结果显示，与对照组相比，脱发疾病患者表皮和毛囊中Erdr1的表达显著下调。特别是，斑秃患者中Erdr1的表达明显降低。我们认为，Erdr1下调可能参与脱发的发病机制，并可被视为脱发疾病的一种新型生物标志物。
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