Istrătoaie Octavian, Pirici Ionica, OfiŢeru Anca Maria, Grosu Florin, Brînzea Alice, Olar Lavinia, Efrem Ion Cristian
Department of Anatomy, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2016;57(4):1351-1356.
Myocardial fibrosis is one of the most common histopathological lesions found in chronic heart diseases. Progressive development of myocardial fibrosis will cause heart failure, an extremely debilitating and life threatening condition. The correlation between the severity of fibrosis and myocardial microcirculation is an important prognostic factor in this disease entity. In our study, myocardial microvascular density evaluation of the patients with high blood pressure (hypertension), atrial fibrillation (AF), coronary heart disease, and heart failure showed a significant decrease of the values of this parameter, which means that myocardial fibrosis is the direct result of stimulation of myocardial fibroblasts induced by local hypoxia.
心肌纤维化是慢性心脏病中最常见的组织病理学病变之一。心肌纤维化的进行性发展会导致心力衰竭，这是一种极其虚弱且危及生命的状况。纤维化严重程度与心肌微循环之间的相关性是该疾病实体的一个重要预后因素。在我们的研究中，对高血压、心房颤动（房颤）、冠心病和心力衰竭患者的心肌微血管密度评估显示，该参数值显著降低，这意味着心肌纤维化是局部缺氧诱导心肌成纤维细胞刺激的直接结果。
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