Mathew Jobin, Paulose Cheramadathikudyl Scariya
.Department of Zoology, CMS College Kottayam, Kerala, India.
Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin, Kerala, India.
Acta Neuropsychiatr. 2011 Aug;23(4):145-155. doi: 10.1111/j.1601-5215.2011.00578.x.
Neuroendocrine system plays an important role in modulating our body functions and emotions. At the same time, emotions implicate a pivotal role in the regulation of brain function and neuroendocrine system. Negative affective states such as depression and stress are associated with premature mortality and increase the risk of various fatal diseases. It has been suggested that positive affective states are protective and improve our health and productiveness. Several potential mechanisms have been posited to account for these associations including improved health behaviour, direct physiological benefits, enhanced resistance and recovery from stress among individuals with high versus low positive emotional resources. This review summarises information concerning the neuronal and hormonal systems in mood, impact of negative and positive affective states on the level of cortisol, epinephrine, serotonin, dopamine and endorphins. The functional correlation of neuronal and hormonal systems in the development of diseases and their ability to enhance health-relevant biological processes are also evaluated.
神经内分泌系统在调节我们的身体功能和情绪方面发挥着重要作用。同时，情绪在大脑功能和神经内分泌系统的调节中也起着关键作用。诸如抑郁和压力等负面情绪状态与过早死亡相关，并增加了患各种致命疾病的风险。有人提出，积极的情绪状态具有保护作用，能改善我们的健康状况和工作效率。人们提出了几种潜在机制来解释这些关联，包括改善健康行为、直接的生理益处、增强抵抗力以及在具有高或低积极情绪资源的个体中从压力中恢复的能力。本综述总结了有关情绪中的神经元和激素系统、负面和正面情绪状态对皮质醇、肾上腺素、血清素、多巴胺和内啡肽水平的影响的信息。还评估了神经元和激素系统在疾病发展中的功能相关性以及它们增强与健康相关的生物学过程的能力。
