5-羟色胺对豚鼠回肠肌间神经元γ-氨基丁酸释放的双重作用。

Dual effects of 5-hydroxytryptamine on the release of gamma-aminobutyric acid from myenteric neurones of the guinea-pig ileum.

作者信息

Shirakawa J, Takeda K, Taniyama K, Tanaka C

机构信息

Department of Pharmacology, Kobe University School of Medicine, Japan.

出版信息

Br J Pharmacol. 1989 Oct;98(2):339-41. doi: 10.1111/j.1476-5381.1989.tb12601.x.

DOI:10.1111/j.1476-5381.1989.tb12601.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854702/

Abstract

The effects of 5-hydroxytryptamine (5-HT) on the release of gamma-aminobutyric acid (GABA) were examined in the longitudinal muscle-myenteric plexus (LM-MP) preparation of guinea-pig ileum. 5-HT increased the spontaneous release and inhibited the electrically-evoked release of [3H]-GABA. The 5-HT-evoked release was Ca2+-dependent and tetrodotoxin-sensitive, and was antagonized by (3 alpha-tropanyl)-1H-indole-3-carboxylic acid ester (ICS 205-930), but not by methysergide and ketanserin. The inhibitory effect of 5-HT was antagonized by methysergide, but not by ketanserin and ICS 205-930. 8-Hydroxy-2-(di-n-propylamino)tetralin mimicked the inhibitory effect of 5-HT. Thus, 5-HT may exert an excitatory effect on the enteric GABAergic neurone via the 5-HT3 receptor and an inhibitory effect via the 5-HT1A receptor.

摘要

在豚鼠回肠的纵行肌-肠肌丛（LM-MP）标本中研究了5-羟色胺（5-HT）对γ-氨基丁酸（GABA）释放的影响。5-HT增加了[3H]-GABA的自发释放并抑制了其电诱发释放。5-HT诱发的释放依赖于Ca2+且对河豚毒素敏感，并被（3α-托烷基）-1H-吲哚-3-羧酸酯（ICS 205-930）拮抗，但不受麦角新碱和酮色林的拮抗。5-HT的抑制作用被麦角新碱拮抗，但不受酮色林和ICS 205-930的拮抗。8-羟基-2-（二正丙基氨基）四氢萘模拟了5-HT的抑制作用。因此，5-HT可能通过5-HT3受体对肠内GABA能神经元发挥兴奋作用，并通过5-HT1A受体发挥抑制作用。

相似文献

1

Dual effects of 5-hydroxytryptamine on the release of gamma-aminobutyric acid from myenteric neurones of the guinea-pig ileum.5-羟色胺对豚鼠回肠肌间神经元γ-氨基丁酸释放的双重作用。

Br J Pharmacol. 1989 Oct;98(2):339-41. doi: 10.1111/j.1476-5381.1989.tb12601.x.

2

Uptake and stimulus-evoked release of [3H]-gamma-aminobutyric acid by myenteric nerves of guinea-pig intestine.豚鼠肠道肌间神经对[3H]-γ-氨基丁酸的摄取及刺激诱发释放

Br J Pharmacol. 1983 Feb;78(2):271-6. doi: 10.1111/j.1476-5381.1983.tb09391.x.

3

Myenteric 5-HT-containing neurones activate the descending cholinergic excitatory pathway to the circular muscle of guinea-pig ileum.肠肌层含5-羟色胺的神经元激活豚鼠回肠环形肌的下行胆碱能兴奋性通路。

Br J Pharmacol. 1989 Nov;98(3):982-8. doi: 10.1111/j.1476-5381.1989.tb14629.x.

4

Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus.豚鼠肌间神经丛胆碱能神经上5-羟色胺的两种受体类型。

Br J Pharmacol. 1985 Jun;85(2):529-39. doi: 10.1111/j.1476-5381.1985.tb08890.x.

5

Effects of 5-HT4 receptor stimulation on basal and electrically evoked release of acetylcholine from guinea-pig myenteric plexus.5-羟色胺4受体刺激对豚鼠肠肌丛乙酰胆碱基础释放及电诱发释放的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1992 Mar;345(3):270-5. doi: 10.1007/BF00168686.

6

5-hydroxytryptamine releases adenosine 5'-triphosphate from nerve varicosities isolated from the myenteric plexus of guinea-pig ileum.5-羟色胺从豚鼠回肠肌间神经丛分离出的神经膨体中释放三磷酸腺苷。

Br J Pharmacol. 1985 Jan;84(1):27-34.

7

Serotonin-induced increase in cAMP in ganglia isolated from the myenteric plexus of the guinea pig small intestine: mediation by a novel 5-HT receptor.血清素诱导豚鼠小肠肌间神经丛分离神经节中cAMP增加：由一种新型5-羟色胺受体介导

Synapse. 1993 Apr;13(4):333-49. doi: 10.1002/syn.890130406.

8

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin.西格玛受体调节电刺激和外源性血清素引起的豚鼠回肠纵肌/肠肌间神经丛标本的收缩。

J Neurosci. 1989 Oct;9(10):3380-91. doi: 10.1523/JNEUROSCI.09-10-03380.1989.

9

Substance P provoked gamma-aminobutyric acid release from the myenteric plexus of the guinea-pig small intestine.P物质可促使豚鼠小肠肌间神经丛释放γ-氨基丁酸。

J Physiol. 1985 May;362:319-29. doi: 10.1113/jphysiol.1985.sp015680.

10

Gamma-aminobutyrate as an autonomic neurotransmitter: release and uptake of [3H]gamma-aminobutyrate in guinea pig large intestine and cultured enteric neurons using physiological methods and electron microscopic autoradiography.γ-氨基丁酸作为一种自主神经递质：利用生理学方法和电子显微镜放射自显影术研究豚鼠大肠和培养的肠神经元中[³H]γ-氨基丁酸的释放与摄取

Neuroscience. 1983 Dec;10(4):1427-42. doi: 10.1016/0306-4522(83)90124-0.

引用本文的文献

1

Contractile effects of 5-hydroxytryptamine and 5-carboxamidotryptamine in the equine jejunum.5-羟色胺和5-羧基酰胺色胺对马空肠的收缩作用。

Br J Pharmacol. 2006 Jan;147(1):23-35. doi: 10.1038/sj.bjp.0706431.

本文引用的文献

1

gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum.豚鼠回肠中的γ-氨基丁酸与胆碱能传递

Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):216-20. doi: 10.1007/BF00500768.

2

Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus.豚鼠肌间神经丛胆碱能神经上5-羟色胺的两种受体类型。

Br J Pharmacol. 1985 Jun;85(2):529-39. doi: 10.1111/j.1476-5381.1985.tb08890.x.

3

Presynaptic muscarinic and alpha-adrenoceptor-mediated regulation of GABA release from myenteric neurones of the guinea-pig small intestine.豚鼠小肠肌间神经元中突触前毒蕈碱和α-肾上腺素能受体介导的γ-氨基丁酸释放调节

Br J Pharmacol. 1986 Dec;89(4):787-92. doi: 10.1111/j.1476-5381.1986.tb11183.x.

4

gamma-Aminobutyric acid in peripheral tissues.外周组织中的γ-氨基丁酸

Life Sci. 1985 Dec 16;37(24):2221-35. doi: 10.1016/0024-3205(85)90013-x.

5

BRL 24924: a potent agonist at a non-classical 5-HT receptor positively coupled with adenylate cyclase in colliculi neurons.BRL 24924：一种对非经典5-羟色胺受体有强效激动作用的物质，该受体在丘脑中的神经元中与腺苷酸环化酶正性偶联。

Eur J Pharmacol. 1989 Mar 21;162(2):381-4. doi: 10.1016/0014-2999(89)90304-x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。