Mattson M P
Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536-0230.
Brain Res. 1989 Sep 18;497(2):402-6. doi: 10.1016/0006-8993(89)90289-8.
Glutamate-induced neurodegeneration in the mammalian central nervous system may be involved in both normal development and pathological neurodegenerative disorders. Cultured embryonic hippocampal pyramidal neurons were used to test the hypothesis that acetylcholine can modify glutamate-induced neurodegeneration. Acetylcholine potentiated the neurodegenerative actions of glutamate and lowered the threshold for glutamate neurotoxicity. The degeneration-potentiating effects of acetylcholine were mediated by muscarinic receptors. These results emphasize the importance of neurotransmitter interactions in the modification of neuroarchitecture.
谷氨酸诱导的哺乳动物中枢神经系统神经退行性变可能与正常发育和病理性神经退行性疾病都有关。培养的胚胎海马锥体神经元被用于检验乙酰胆碱可以改变谷氨酸诱导的神经退行性变这一假说。乙酰胆碱增强了谷氨酸的神经退行性作用并降低了谷氨酸神经毒性的阈值。乙酰胆碱的变性增强作用由毒蕈碱受体介导。这些结果强调了神经递质相互作用在神经结构改变中的重要性。
