• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

伊维菌素:神秘的多面“神奇”药物不断带来惊喜并超出预期。

Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations.

作者信息

Crump Andy

机构信息

Graduate School of Infection Control Sciences, Kitasato University, Minato-Ku, Japan.

出版信息

J Antibiot (Tokyo). 2017 May;70(5):495-505. doi: 10.1038/ja.2017.11. Epub 2017 Feb 15.

DOI:10.1038/ja.2017.11
PMID:28196978
Abstract

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

摘要

在过去十年中,全球科学界开始认识到一种非凡药物——伊维菌素的独特价值,它源自从日本土壤中发现的一种单一微生物。伊维菌素的研究成果使它的发现者、东京著名的北里研究所的大村智获得了2014年盖尔德纳全球健康奖以及2015年诺贝尔生理学或医学奖,他与该药物发现和开发的合作伙伴、默克公司的威廉·坎贝尔共同获得这一奖项。如今,伊维菌素不断给科学家带来惊喜,它有望通过治疗多种疾病来改善全球公共卫生状况,其作为抗菌、抗病毒和抗癌药物的意外潜力尤为突出。

相似文献

1
Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations.伊维菌素:神秘的多面“神奇”药物不断带来惊喜并超出预期。
J Antibiot (Tokyo). 2017 May;70(5):495-505. doi: 10.1038/ja.2017.11. Epub 2017 Feb 15.
2
Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin.对 2015 年诺贝尔医学奖的思考——阿维菌素和青蒿素的公共卫生遗产和影响。
Trends Parasitol. 2015 Dec;31(12):605-607. doi: 10.1016/j.pt.2015.10.008. Epub 2015 Nov 6.
3
Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi Ōmura.庆祝大村智博士荣获2015年诺贝尔生理学或医学奖。
J Antibiot (Tokyo). 2016 Jan;69(1):1. doi: 10.1038/ja.2015.113. Epub 2015 Oct 21.
4
The advent of ivermectin: people, partnerships, and principles.伊维菌素的出现:人与合作,以及原则。
Trends Parasitol. 2014 Sep;30(9):423-5. doi: 10.1016/j.pt.2014.07.001.
5
Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine.2015年诺贝尔生理学或医学奖得主威廉·C·坎贝尔、大村智和屠呦呦简介。
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15773-6. doi: 10.1073/pnas.1520952112. Epub 2015 Dec 22.
6
The Nobel Prize in Medicine 2015: Two drugs that changed global health.2015年诺贝尔医学奖:两种改变全球健康状况的药物。
Sci Transl Med. 2015 Dec 2;7(316):316ed14. doi: 10.1126/scitranslmed.aad5868.
7
Introduction of the 2016 ASP Eminent Parasitologist Recipient.2016年美国寄生虫学会杰出寄生虫学家奖获得者介绍。
J Parasitol. 2016 Dec;102(6):572. doi: 10.1645/16-134. Epub 2016 Sep 27.
8
Epoch-making milestones in antibiotic exploratory researches in Japan.日本抗生素探索性研究中的划时代里程碑。
Biosci Biotechnol Biochem. 2017 Jan;81(1):23-27. doi: 10.1080/09168451.2016.1248372.
9
History of avermectin and ivermectin, with notes on the history of other macrocyclic lactone antiparasitic agents.阿维菌素和伊维菌素的历史,以及其他大环内酯类抗寄生虫药物的历史注释。
Curr Pharm Biotechnol. 2012 May;13(6):853-65. doi: 10.2174/138920112800399095.
10
Anti-parasite drugs sweep Nobel prize in medicine 2015.抗寄生虫药物荣获2015年诺贝尔医学奖。
Nature. 2015 Oct 8;526(7572):174-5. doi: 10.1038/nature.2015.18507.

引用本文的文献

1
Variations in Plasma Levels of Orally Administered Ivermectin Could Hamper Its Potential Drug Repositioning: Results of a Bioequivalence Study in Mexican Population.口服伊维菌素血浆水平的差异可能会阻碍其潜在的药物重新定位:墨西哥人群生物等效性研究的结果。
Pharmaceuticals (Basel). 2025 Aug 13;18(8):1193. doi: 10.3390/ph18081193.
2
Context-Dependent Effects of Ivermectin Residues on Dung Insects: Interactions With Environmental Stressors, Size, and Sex in a Sepsid Fly ().伊维菌素残留对粪栖昆虫的环境依赖性影响:与一种蚤蝇的环境应激源、体型及性别的相互作用
Ecol Evol. 2025 Aug 8;15(8):e71929. doi: 10.1002/ece3.71929. eCollection 2025 Aug.
3
Comparative susceptibility of wild and laboratory-reared Aedes and Anopheles larvae to ivermectin.
野生和实验室饲养的伊蚊和按蚊幼虫对伊维菌素的敏感性比较。
Malar J. 2025 Jul 8;24(1):222. doi: 10.1186/s12936-025-05470-y.
4
Antiproliferative and Trypanocidal Activity of Ivermectin Bioconjugates.伊维菌素生物共轭物的抗增殖和杀锥虫活性
ACS Omega. 2025 Jun 18;10(25):27380-27392. doi: 10.1021/acsomega.5c02998. eCollection 2025 Jul 1.
5
Current perspectives in the epidemiology and control of lymphatic filariasis.淋巴丝虫病流行病学与防治的当前观点
Clin Microbiol Rev. 2025 Jun 12;38(2):e0012623. doi: 10.1128/cmr.00126-23. Epub 2025 Apr 2.
6
Efficacy and Safety of Albendazole Versus Albendazole and Ivermectin in Reduction of Soil-Transmitted Helminth Infections in School-Age Children (DVERMIN): A Double-Blind, Randomized, Controlled Trial.阿苯达唑与阿苯达唑和伊维菌素对降低学龄儿童土壤传播蠕虫感染的疗效与安全性比较(DVERMIN):一项双盲、随机、对照试验
Cureus. 2025 Feb 17;17(2):e79152. doi: 10.7759/cureus.79152. eCollection 2025 Feb.
7
The impact of ivermectin on COVID-19 outcomes: a systematic review and meta-analysis.伊维菌素对COVID-19结局的影响:一项系统评价和荟萃分析。
Ann Med Surg (Lond). 2025 Jan 7;87(2):809-829. doi: 10.1097/MS9.0000000000002762. eCollection 2025 Feb.
8
Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway.伊维菌素通过激活ATF4介导的内质网应激-自噬途径来抑制食管鳞状细胞癌的生长。
Acta Biochim Biophys Sin (Shanghai). 2024 Nov 22;57(6):995-1005. doi: 10.3724/abbs.2024210.
9
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7.筛选草药和天然产物文库以助力发现人P2X7新型变构调节剂。
Purinergic Signal. 2025 Apr;21(2):365-379. doi: 10.1007/s11302-024-10055-6. Epub 2024 Oct 22.
10
Doramectin Induces Apoptosis in B16 Melanoma Cells.多拉菌素诱导B16黑色素瘤细胞凋亡。
Anticancer Agents Med Chem. 2025;25(4):244-256. doi: 10.2174/0118715206325844240909144543.