利用扩散磁共振技术评估类淋巴系统活性：阿尔茨海默病病例中沿血管周围间隙的扩散张量图像分析（DTI-ALPS）
Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases.
作者信息
Taoka Toshiaki, Masutani Yoshitaka, Kawai Hisashi, Nakane Toshiki, Matsuoka Kiwamu, Yasuno Fumihiko, Kishimoto Toshifumi, Naganawa Shinji
机构信息
Department of Radiology, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1, Ozuka-Higashi, Asa-Minami-Ku, Hiroshima, 731-3194, Japan.
出版信息
Jpn J Radiol. 2017 Apr;35(4):172-178. doi: 10.1007/s11604-017-0617-z. Epub 2017 Feb 14.
PURPOSE
The activity of the glymphatic system is impaired in animal models of Alzheimer's disease (AD). We evaluated the activity of the human glymphatic system in cases of AD with a diffusion-based technique called diffusion tensor image analysis along the perivascular space (DTI-ALPS).
MATERIALS AND METHODS
Diffusion tensor images were acquired to calculate diffusivities in the x, y, and z axes of the plane of the lateral ventricle body in 31 patients. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers separately, to acquire an index for diffusivity along the perivascular space (ALPS-index) and correlated them with the mini mental state examinations (MMSE) score.
RESULTS
We found a significant negative correlation between diffusivity along the projection fibers and association fibers. We also observed a significant positive correlation between diffusivity along perivascular spaces shown as ALPS-index and the MMSE score, indicating lower water diffusivity along the perivascular space in relation to AD severity.
CONCLUSION
Activity of the glymphatic system may be evaluated with diffusion images. Lower diffusivity along the perivascular space on DTI-APLS seems to reflect impairment of the glymphatic system. This method may be useful for evaluating the activity of the glymphatic system.
目的
在阿尔茨海默病（AD）动物模型中，类淋巴系统的活性受损。我们使用一种基于扩散的技术，即沿血管周围间隙的扩散张量图像分析（DTI - ALPS），评估AD患者中人类类淋巴系统的活性。
材料与方法
采集31例患者侧脑室体平面x、y和z轴的扩散张量图像以计算扩散率。我们分别评估沿血管周围间隙以及投射纤维和联合纤维的扩散率，以获取沿血管周围间隙的扩散率指数（ALPS指数），并将其与简易精神状态检查（MMSE）评分相关联。
结果
我们发现沿投射纤维和联合纤维的扩散率之间存在显著负相关。我们还观察到以ALPS指数表示的沿血管周围间隙的扩散率与MMSE评分之间存在显著正相关，这表明相对于AD严重程度，沿血管周围间隙的水扩散率较低。
结论
类淋巴系统的活性可用扩散图像进行评估。DTI - APLS上沿血管周围间隙的较低扩散率似乎反映了类淋巴系统的损伤。该方法可能有助于评估类淋巴系统的活性。
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