John Hunter Children's Hospital, Newcastle, NSW
Telethon Kids, Perth, WA.
Med J Aust. 2017 Feb 20;206(3):121-125. doi: 10.5694/mja16.00737.
To assess glycaemic control, anthropometry and insulin regimens in a national sample of Australian children and adolescents with type 1 diabetes.
Cross-sectional analysis of de-identified, prospectively collected data from the Australasian Diabetes Data Network (ADDN) registry.
Five paediatric diabetes centres in New South Wales, Queensland, South Australia, Victoria and Western Australia.
Children and adolescents (aged 18 years or under) with type 1 diabetes of at least 12 months' duration for whom data were added to the ADDN registry during 2015.
Glycaemic control was assessed by measuring haemoglobin A1c (HbA1c) levels. Body mass index standard deviation scores (BMI-SDS) were calculated according to the CDC-2000 reference; overweight and obesity were defined by International Obesity Task Force guidelines. Insulin regimens were classified as twice-daily injections (BD), multiple daily injections (MDI; at least three injection times per day), or continuous subcutaneous insulin infusion (CSII).
The mean age of the 3279 participants was 12.8 years (SD, 3.7), mean diabetes duration was 5.7 years (SD, 3.7), and mean HbA1c level 67 mmol/mol (SD, 15); only 27% achieved the national HbA1c target of less than 58 mmol/mol. The mean HbA1c level was lower in children under 6 (63 mmol/mol) than in adolescents (14-18 years; 69 mmol/mol). Mean BMI-SDS for all participants was 0.6 (SD, 0.9); 33% of the participants were overweight or obese. 44% were treated with CSII, 38% with MDI, 18% with BD.
Most Australian children and adolescents with type 1 diabetes are not meeting the recognised HbA1c target. The prevalence of overweight and obesity is high. There is an urgent need to identify barriers to achieving optimal glycaemic control in this population.
评估澳大利亚患有 1 型糖尿病的儿童和青少年的血糖控制、人体测量和胰岛素方案。
对来自澳大利亚糖尿病数据网络(ADDN)登记处的前瞻性收集的匿名数据进行横断面分析。
新南威尔士州、昆士兰州、南澳大利亚州、维多利亚州和西澳大利亚州的五家儿科糖尿病中心。
至少患有 12 个月 1 型糖尿病的儿童和青少年(年龄在 18 岁或以下),在 2015 年期间,他们的数据被添加到 ADDN 登记处。
通过测量糖化血红蛋白(HbA1c)水平来评估血糖控制情况。根据 CDC-2000 参考标准计算体重指数标准差评分(BMI-SDS);根据国际肥胖问题工作组的指南,超重和肥胖的定义。胰岛素方案分为每日两次注射(BD)、多次每日注射(MDI;每天至少注射三次)或持续皮下胰岛素输注(CSII)。
3279 名参与者的平均年龄为 12.8 岁(标准差,3.7),平均糖尿病病程为 5.7 年(标准差,3.7),平均 HbA1c 水平为 67mmol/mol(标准差,15);只有 27%的人达到了低于 58mmol/mol 的国家 HbA1c 目标。6 岁以下儿童的平均 HbA1c 水平(63mmol/mol)低于青少年(14-18 岁;69mmol/mol)。所有参与者的平均 BMI-SDS 为 0.6(标准差,0.9);33%的参与者超重或肥胖。44%的人接受 CSII 治疗,38%的人接受 MDI 治疗,18%的人接受 BD 治疗。
大多数澳大利亚患有 1 型糖尿病的儿童和青少年都未达到公认的 HbA1c 目标。超重和肥胖的患病率很高。迫切需要确定该人群实现最佳血糖控制的障碍。