N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801可减弱麻醉大鼠的贝佐尔德-雅里什反射。

The N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, attenuates the Bezold-Jarisch reflex in the anaesthetized rat.

作者信息

Verberne A J, Costa M, Lewis S J, Louis W J, Beart P M

机构信息

University of Melbourne, Department of Medicine, Austin, Hospital, Heidelberg, Victoria, Australia.

出版信息

Neuropharmacology. 1987 Aug;26(8):1243-6. doi: 10.1016/0028-3908(87)90277-2.

DOI:10.1016/0028-3908(87)90277-2

PMID:2821444

Abstract

The effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, on the Bezold-Jarisch reflex elicited by i.v. doses of 5-hydroxytryptamine (5-HT) was investigated in urethane-anaesthetized rats. Activation of the Bezold-Jarisch reflex with 5-HT (0.5-16 microgram/kg) produced pronounced dose-dependent hypotensive and bradycardic responses which were attenuated by MK-801 (1 mg/kg, i.v.) but not by saline. The data suggests that activation of the Bezold-Jarisch reflex by 5-HT involves a glutamatergic synapse presumably located within the brainstem vagal reflex arc.

摘要

在乌拉坦麻醉的大鼠中，研究了N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801对静脉注射5-羟色胺（5-HT）引发的贝佐尔德-雅里什反射的影响。用5-HT（0.5 - 16微克/千克）激活贝佐尔德-雅里什反射会产生明显的剂量依赖性低血压和心动过缓反应，这些反应可被MK-801（1毫克/千克，静脉注射）减弱，但生理盐水无此作用。数据表明，5-HT激活贝佐尔德-雅里什反射涉及一个可能位于脑干迷走神经反射弧内的谷氨酸能突触。