Hayakawa Y, Hyman R W
Department of Microbiology, Pennsylvania State University, College of Medicine, Hershey 17033.
Virus Res. 1987 Jul;8(1):25-31. doi: 10.1016/0168-1702(87)90037-2.
Varicella-zoster virus (VZV) DNA exists principally as two isomers. Despite the presence of inverted repeats bounding the long sequence region, the unique long sequence, UL, is found in one (prototype) orientation in 95-98% of VZV DNA molecules and in the inverted orientation in only 2-5% of the molecules. In searching for an explanation for this disparity, we superinfected VZV-infected cells with herpes simplex virus type 1 or pseudorabies virus. Neither superinfecting virus produced a measurable change in the frequency of isomerization of the VZV DNA long sequence region.
