Xia Yufa, Wu Dan, Gao Zhifan, Liu Xin, Chen Qian, Ren Lijie, Wu Wanqing
Research Center for Biomedical Information Technology, Shenzhen Institute of Advance Technology, Chinese Academic of Science Shenzhen Children Hospital Department of Neurology, Shenzhen Second People's Hospital, Futian District Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences,Shenzhen University Town, Shenzhen, China.
Medicine (Baltimore). 2017 Feb;96(8):e6000. doi: 10.1097/MD.0000000000006000.
The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). The CPT included 3 phases: baseline phase, cold stimulus phase, recovery phase. Six parameters were used to estimate BPV. In bivariate correlation analysis, TAC showed a significant correlation with systolic BP (SBP) and diastolic BP (DBP) in the cold stimulus phase; and 4 indices of SBP variability (SBPV) were associated with TAC (r = 0.271∼0.331, P ≤ 0.015) in the recovery phase; similarly, 2 indices of DBP variability (DBPV) were also correlated with TAC (r = 0.221∼0.285, P ≤ 0.048) in the recovery phase. In multivariate regression analysis, DBPV (β = 0.229, P = 0.001) was a determinant of TAC independent of average DBP, sex, and weight. In addition, both beat-to-beat BP and BPV values increased in the cold stimulus phase (P < 0.01); whereas, the TAC decreased in the cold stimulus phase (P < 0.01). In conclusion, these data suggest that the beat-to-beat DBPV shows an independent association with the vascular elasticity in young normal adults during the CPT.
逐搏血压（BP）监测参数，如平均逐搏血压、血压变异性（BPV），可能会对血管弹性产生影响。本研究假设，升高的逐搏BPV可引起血管弹性降低，且与血压水平无关。我们在80名年轻健康成年人进行冷加压试验（CPT）期间测量了逐搏BP记录和总动脉顺应性（TAC），后者用于评估血管弹性。CPT包括3个阶段：基线期、冷刺激期、恢复期。使用6个参数来估计BPV。在双变量相关性分析中，TAC在冷刺激期与收缩压（SBP）和舒张压（DBP）显著相关；在恢复期，4个SBP变异性（SBPV）指标与TAC相关（r = 0.271∼0.331，P≤0.015）；同样，在恢复期，2个DBP变异性（DBPV）指标也与TAC相关（r = 0.221∼0.285，P≤0.048）。在多变量回归分析中，DBPV（β = 0.229，P = 0.001）是TAC的一个决定因素，独立于平均DBP、性别和体重。此外，在冷刺激期，逐搏BP和BPV值均升高（P < 0.01）；而在冷刺激期，TAC降低（P < 0.01）。总之，这些数据表明，在CPT期间，年轻正常成年人的逐搏DBPV与血管弹性呈独立相关性。
