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沉默利钠肽-β可减轻自发性高血压大鼠的心血管重塑和高血压。

Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats.

机构信息

Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

Department of Pathophysiology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

出版信息

Sci Rep. 2017 Feb 23;7:43259. doi: 10.1038/srep43259.

DOI:10.1038/srep43259
PMID:28230187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5322393/
Abstract

Salusin-β is a bioactive peptide involved in vascular smooth muscle cell proliferation, vascular fibrosis and hypertension. The present study was designed to determine the effects of silencing salusin-β on hypertension and cardiovascular remodeling in spontaneously hypertensive rats (SHR). Thirteen-week-old male SHR and normotensive Wistar-Kyoto rats (WKY) were subjected to intravenous injection of PBS, adenoviral vectors encoding salusin-β shRNA (Ad-Sal-shRNA) or a scramble shRNA. Salusin-β levels in plasma, myocardium and mesenteric artery were increased in SHR. Silencing salusin-β had no significant effect on blood pressure in WKY, but reduced blood pressure in SHR. It reduced the ratio of left ventricle weight to body weight, cross-sectional areas of cardiocytes and perivascular fibrosis, and decreased the media thickness and the media/lumen ratio of arteries in SHR. Silencing salusin-β almost normalized plasma norepinephrine and angiotensin II levels in SHR. It prevented the upregulation of angiotensin II and AT receptors, and reduced the NAD(P)H oxidase activity and superoxide anion levels in myocardium and mesenteric artery of SHR. Knockdown of salusin-β attenuated cell proliferation and fibrosis in vascular smooth muscle cells from SHR. These results indicate that silencing salusin-β attenuates hypertension and cardiovascular remodeling in SHR.

摘要

沙利素-β是一种参与血管平滑肌细胞增殖、血管纤维化和高血压的生物活性肽。本研究旨在确定沉默沙利素-β对自发性高血压大鼠（SHR）高血压和心血管重构的影响。将 13 周龄雄性 SHR 和正常血压的 Wistar-Kyoto 大鼠（WKY）分别给予 PBS、携带沙利素-β shRNA（Ad-Sal-shRNA）或乱序 shRNA 的腺病毒载体静脉注射。SHR 血浆、心肌和肠系膜动脉中的沙利素-β水平升高。沉默沙利素-β对 WKY 的血压没有显著影响，但降低了 SHR 的血压。它降低了 SHR 左心室重量与体重的比值、心肌细胞的横截面积和血管周围纤维化程度，并降低了 SHR 动脉的中膜厚度和中膜/腔比。沉默沙利素-β几乎使 SHR 血浆去甲肾上腺素和血管紧张素 II 水平正常化。它阻止了心肌和肠系膜动脉中血管紧张素 II 和 AT 受体的上调，并降低了 NAD(P)H 氧化酶活性和超氧阴离子水平。沉默沙利素-β可减轻 SHR 血管平滑肌细胞的增殖和纤维化。这些结果表明，沉默沙利素-β可减轻 SHR 的高血压和心血管重构。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9aac/5322393/099a9cec732c/srep43259-f8.jpg
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Resveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension.白藜芦醇通过AMPK抑制Rac1衍生的活性氧，降低果糖诱导的高血压大鼠模型的血压。
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Salusin-β in Intermediate Dorsal Motor Nucleus of the Vagus Regulates Sympathetic-Parasympathetic Balance and Blood Pressure.迷走神经中间背侧运动核中的Salusin-β调节交感-副交感神经平衡和血压。
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