基于酰腙卤化物和二肼基噻二唑的噻二唑、双噻二唑、噻二唑并三嗪和吡唑并噻二唑的新路线合成

Sayed Abdelwahed R, Al-Shihry Shar Saad

Department of Chemistry, Faculty of Science, King Faisal University, Hofuf 31982, Saudi Arabia.

Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.

Molecules. 2017 Feb 21;22(2):336. doi: 10.3390/molecules22020336.

Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied. Treatment of hydrazonoyl halides with 2,5-dihydrazinyl-1,3,4-thiadiazole afforded new bistriazines containing thiadiazole; we also examined the reaction of 2,5-dihydrazinyl-1,3,4-thiadiazole with active methylene compounds to afford new pyrazoles containing thiadiazole compounds. The new synthesized compounds were identified by elemental analysis and various spectral data (Fourier transform infrared spectroscopy, mass spectrometry, 1H and 13C nuclear magnetic resonance).

研究了单肼基卤化物和二肼基卤化物与各种肼基碳二硫代酸酯衍生物反应生成新型噻二唑、双噻二唑的合成及表征。用2,5 - 二肼基 - 1,3,4 - 噻二唑处理肼基卤化物得到含噻二唑的新型双三嗪；我们还研究了2,5 - 二肼基 - 1,3,4 - 噻二唑与活性亚甲基化合物的反应，以得到含噻二唑化合物的新型吡唑。通过元素分析和各种光谱数据（傅里叶变换红外光谱、质谱、1H和13C核磁共振）对新合成的化合物进行了鉴定。