McAvoy Mark, Mitra Anish, Tagliazucchi Enzo, Laufs Helmut, Raichle Marcus E
Department of Radiology, Washington University, Saint Louis, MO 63110, USA.
Institute for Medical Psychology, Christian-Albrechts-Universitat zu Kiel, Kiel, Germany; Department of Neurology, Brain Imaging Center, Goethe-Universitat Frankfurt am Main, Frankfurt, Germany.
Neuroimage. 2017 Apr 15;150:250-261. doi: 10.1016/j.neuroimage.2017.02.053. Epub 2017 Feb 21.
Sleep is a universal behavior, essential for humans and animals alike to survive. Its importance to a person's physical and mental health cannot be overstated. Although lateralization of function is well established in the lesion, split-brain and task based neuroimaging literature, and more recently in functional imaging studies of spontaneous fluctuations of the fMRI BOLD signal during wakeful rest, it is unknown if these asymmetries are present during sleep. We investigated hemispheric asymmetries in the global brain signal during non-REM sleep. Here we show that increasing sleep depth is accompanied by an increasing rightward asymmetry of regions in visual cortex including primary bilaterally and in the right hemisphere along the lingual gyrus and middle temporal cortex. In addition, left hemisphere language regions largely maintained their leftward asymmetry during sleep. Right hemisphere attention related regions expressed a more complicated relation with some regions maintaining a rightward asymmetry while this was lost in others. These results suggest that asymmetries in the human brain are state dependent.
睡眠是一种普遍行为，对人类和动物的生存都至关重要。其对一个人的身心健康的重要性无论如何强调都不为过。尽管功能偏侧化在损伤、裂脑和基于任务的神经影像学文献中已得到充分证实，最近在清醒休息期间功能磁共振成像血氧水平依赖（BOLD）信号自发波动的功能成像研究中也得到证实，但尚不清楚这些不对称性在睡眠期间是否存在。我们研究了非快速眼动睡眠期间全脑信号的半球不对称性。在此我们表明，睡眠深度增加伴随着视觉皮层区域向右不对称性的增加，这些区域包括双侧初级视觉皮层以及右侧半球沿舌回和颞中皮层的区域。此外，左半球语言区域在睡眠期间基本保持其向左不对称性。右半球与注意力相关的区域表现出更复杂的关系，一些区域保持向右不对称性，而其他区域则失去了这种不对称性。这些结果表明，人脑的不对称性取决于状态。
