Soh J Y, Chiang W C, Huang C H, Woo C K, Ibrahim I, Heng K, Pramanick A, Lee B W
Department of Paediatrics, National University Hospital, Tower Block Level 12, 1E Kent Ridge Road, Singapore, 119228 Singapore ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Department of Paediatrics, Kandang Kerbau Women's and Children's Hospital, Singapore, Singapore.
World Allergy Organ J. 2017 Feb 10;10(1):3. doi: 10.1186/s40413-016-0136-x. eCollection 2017.
Galacto-oligosaccharides (GOS) are prebiotics added to commercial milk formula of infants and mothers. In recent years, cases of allergy related to GOS in atopic children have been reported in the South East Asian region.
We describe a series of pregnant ( = 4) and lactating mothers ( = 2) who developed anaphylactic reactions after consumption of maternal milk formula containing GOS. All six subjects had pre-existing atopy and a positive skin prick test to GOS and 5/5 of the subjects who were tested had positive basophil activation tests to GOS. All of the mothers and their babies had normal neonatal outcomes after the reactions.
The supplementation of GOS into milk and beverages in the Asian region should take into account the rare chance of allergenicity of GOS in the atopic population.
低聚半乳糖（GOS）是添加到婴幼儿和孕产妇商业配方奶粉中的益生元。近年来，东南亚地区已有关于特应性儿童食用GOS后发生过敏的病例报道。
我们描述了一系列食用含GOS的孕产妇配方奶粉后发生过敏反应的孕妇（n = 4）和哺乳期母亲（n = 2）。所有6名受试者既往均有特应性，对GOS的皮肤点刺试验呈阳性，5名接受检测的受试者中有5名对GOS的嗜碱性粒细胞活化试验呈阳性。所有母亲及其婴儿在过敏反应后均获得了正常的新生儿结局。
在亚洲地区，将GOS添加到牛奶和饮料中时应考虑到GOS在特应性人群中存在罕见的致敏可能性。
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