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[X射线照射后大鼠脑内cAMP依赖性蛋白激酶的自磷酸化对环磷酸腺苷结合的影响]

[Effect of autophosphorylation on binding of cyclic adenosine monophosphate by cAMP-dependent protein kinases from the rat brain after x-irradiation].

作者信息

Ostapchenko L I, Vasil'ev A N, Kucherenko N E

出版信息

Radiobiologiia. 1987 Sep-Oct;27(5):633-6.

PMID:2823310
Abstract

The results of the studies on the influence of autophosphorylation on cAMP binding by cAMP-dependent protein kinases isolated from cytosol and solubilized synaptic membranes have demonstrated that this chain in the regulation of the enzyme forms under study exhibits early radiosensitivity, the radiation damage to soluble and membrane enzymes being differently pronounced.

摘要

关于从胞质溶胶和可溶突触膜中分离出的环磷酸腺苷(cAMP)依赖性蛋白激酶,自磷酸化对其结合cAMP影响的研究结果表明,在所研究的酶形式调节过程中的这条链表现出早期放射敏感性,对可溶性酶和膜酶的辐射损伤表现不同。

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