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[米勒链球菌:免疫功能正常患者颅骨广泛骨髓炎的罕见病因]

[Streptococcus milleri: An unusual cause of skull extensive osteomyelitis in an immunocompetent patient].

作者信息

Duquenne C, Dernis E, Zehrouni A, Bizon A, Duquenne M

机构信息

Service de rhumatologie, centre hospitalier universitaire, 2, avenue Foch, 29609 Brest cedex, France.

Service de rhumatologie, centre hospitalier, 194, avenue Rubillard, 72037 Le Mans cedex 9, France.

出版信息

Rev Med Interne. 2017 Sep;38(9):628-632. doi: 10.1016/j.revmed.2017.01.011. Epub 2017 Feb 22.

Abstract

INTRODUCTION

Streptococcus milleri (Streptococcus anginosus, intermedius and constellatus) are commensal organisms, which can become pathogenic and cause infection with frequent abscess formation, local or metastatic extension. Osteomyelitis of the skull has been rarely reported in this type of infection.

CASE REPORT

Skull osteomyelitis due to Streptococcus milleri is reported in a 61-year-old immunocompetent man without any medical history, occurring 10 months after a head injury without any wound or complication at initial presentation. A progressive right parieto-occipital headache with worsening and increased acute phase reactants evoked a giant cell arteritis. After few days of corticosteroid therapy (0.5 mg/kg/day), diagnosis of subcutaneous abscess associated to an extensive osteomyelitis of the skull due to Streptococcus milleri was diagnosed. The outcome was favorable after drainage of one liter of pus, irrigation, debridement and antibiotherapy by amoxicillin for 8 weeks.

CONCLUSION

It is necessary to discuss the differential diagnosis of giant cell arteritis particularly when symptoms are unusual. Even a short-term corticosteroid therapy may dramatically exacerbate an undetected infection.

摘要

引言

米勒链球菌(包括咽峡炎链球菌、中间型链球菌和星座链球菌)是共生菌,可致病并引发感染,常形成脓肿,出现局部或转移性扩散。这种感染类型中,颅骨骨髓炎鲜有报道。

病例报告

本文报道了一例61岁免疫功能正常的男性患者,既往无病史,在头部受伤10个月后发生米勒链球菌所致的颅骨骨髓炎,受伤初期无伤口或并发症。进行性加重的右侧顶枕部头痛以及急性期反应物升高引发了巨细胞动脉炎的怀疑。在接受了数天的皮质类固醇治疗(0.5毫克/千克/天)后,诊断为米勒链球菌所致的颅骨广泛骨髓炎伴皮下脓肿。引流1升脓液、冲洗、清创并使用阿莫西林进行8周抗生素治疗后,患者预后良好。

结论

有必要讨论巨细胞动脉炎的鉴别诊断,尤其是在症状不典型时。即使是短期的皮质类固醇治疗也可能会显著加重未被发现的感染。

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