Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Centro de Investigacion Medica Aplicada (CIMA), Pamplona, Spain.
Curr Opin Immunol. 2017 Apr;45:73-81. doi: 10.1016/j.coi.2017.01.003. Epub 2017 Feb 23.
Natural Killer (NK) cells are cytotoxic lymphocytes specialized in early defense against virus-infected and transformed cells. NK-cell function is regulated by activating and inhibitory surface receptors recognizing their ligands on transformed cells. Modulation of NK numbers and/or function by a variety of agents such as cytokines and monoclonal antibodies may result in enhanced anti-tumor activity. Recombinant cytokines (i.e., IL-15 and IL-2), antibodies blocking inhibitory receptors (i.e., KIR, NKG2A and TIGIT) and agonists delivering signals via CD137, NKG2D and CD16 stand out as the most suitable opportunities. These agents can be used to potentiate NKcell- mediated antibody-dependent cellular cytotoxicity (ADCC) against antibody-coated tumor cells, offering potential for multiple combinatorial immunotherapy strategies against cancer.
自然杀伤 (NK) 细胞是一种细胞毒性淋巴细胞，专门用于早期防御病毒感染和转化细胞。NK 细胞的功能受识别转化细胞配体的激活和抑制表面受体调节。各种制剂（如细胞因子和单克隆抗体）对 NK 细胞数量和/或功能的调节可能导致抗肿瘤活性增强。重组细胞因子（即 IL-15 和 IL-2）、阻断抑制受体的抗体（即 KIR、NKG2A 和 TIGIT）以及通过 CD137、NKG2D 和 CD16 传递信号的激动剂是最有前途的选择。这些制剂可用于增强针对抗体包被的肿瘤细胞的 NK 细胞介导的抗体依赖性细胞毒性 (ADCC)，为针对癌症的多种组合免疫治疗策略提供了潜力。
