来自流行病学相关质粒的甲氧苄啶抗性基因定位
Mapping of trimethoprim resistance genes from epidemiologically related plasmids.
作者信息
Campbell I G, Mee B J
机构信息
Department of Microbiology, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands.
出版信息
Antimicrob Agents Chemother. 1987 Sep;31(9):1440-1. doi: 10.1128/AAC.31.9.1440.
Abstract
Trimethoprim resistance dihydrofolate reductase genes from plasmids known to be exchanging between human and animal populations were mapped. The dihydrofolate reductase gene has been highly conserved in all plasmids, but differences in the flanking regions provide evidence that the most recent exchange of plasmids between the two ecosystems has been from animals to humans.
摘要
对已知在人类和动物群体之间进行交换的质粒中的甲氧苄啶抗性二氢叶酸还原酶基因进行了定位。二氢叶酸还原酶基因在所有质粒中高度保守，但侧翼区域的差异提供了证据，表明这两个生态系统之间最近的质粒交换是从动物到人类。
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