股动脉内膜中层厚度的遗传度。

Heritability of the femoral intima media thickness.

作者信息

Fejer Bence, Tarnoki Adam D, Tarnoki David L, Lucatelli Pierleone, Littvay Levente, Maurovich-Horvat Pal, Jermendy Adam L, Kovacs Attila, Godor Erika, Fagnani Corrado, Stazi Maria A, Molnar Andrea A, Fanelli Fabrizio, Cirelli Carlo, Farina Filippo, Baracchini Claudio, Meneghetti Giorgio, Pucci Giacomo, Jermendy Gyorgy, Merkely Bela, Schillaci Giuseppe, Medda Emanuela

机构信息

Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary.

Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary; Hungarian Twin Registry, 29 Erdélyi Street, Budapest 1212, Hungary.

出版信息

Eur J Intern Med. 2017 Jun;41:44-48. doi: 10.1016/j.ejim.2017.02.019. Epub 2017 Feb 23.

DOI:10.1016/j.ejim.2017.02.019

PMID:28237540

Abstract

BACKGROUND

The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease.

MATERIALS AND METHODS

388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers.

RESULTS

Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%-65.2%) and 47.2% (95% CI, 31.4%-62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%-78.5%) and 52.8% (95% CI, 37.2%-68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure.

CONCLUSIONS

Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

摘要

背景

尽管股动脉内膜中层厚度（IMT）是心血管疾病的替代标志物，但在临床实践中对其测量的应用并不充分。

材料与方法

388对匈牙利和意大利双胞胎（121对同卵双胞胎，73对异卵双胞胎）接受了双侧股动脉B型超声检查。IMT通过半自动软件（如有）或卡尺进行测量。

结果

同卵双胞胎中各参数的配对内相关性高于异卵双胞胎。年龄、性别和国家校正后的遗传效应分别占股总动脉和股浅动脉IMT变异的43.9%（95%置信区间，CI 21.3%-65.2%）和47.2%（95%CI，31.4%-62.6%），非共享环境效应分别占56.1%（95%CI 34.6%-78.5%）和52.8%（95%CI，37.2%-68.5%）。在校正体重指数或中心收缩压后，这些结果没有显著变化。