Erakovic Haber Vesna, Spaventi Radan
Fidelta d.o.o., Prilaz baruna Filipovića 29, Zagreb, Croatia.
Triadelta Partners d.o.o., Međimurska 19/2, Zagreb, Croatia.
Prog Mol Subcell Biol. 2017;55:91-104. doi: 10.1007/978-3-319-51284-6_3.
Drug discovery and development process is nowadays conducted in relatively standardised sequence of phases, starting with Discovery and being followed by Preclinical, Clinical and Non-Clinical Development. Discovery phase is divided in Hit Finding, Lead generation, Lead Optimisation and Candidate Identification Phase. Main drivers of the whole process are regulatory requirements and the aim to eliminate the unnecessary spending by early elimination of unlikely drug candidates. Marine products, once purified, isolated and produced in required quantities, follow the same route as any other synthetic drug.
如今，药物发现与开发过程按照相对标准化的阶段顺序进行，从发现阶段开始，随后是临床前、临床和非临床开发阶段。发现阶段分为靶点发现、先导化合物生成、先导化合物优化和候选药物鉴定阶段。整个过程的主要驱动因素是监管要求以及通过尽早淘汰不太可能成为药物的候选物来消除不必要支出的目标。海洋产品一旦经过纯化、分离并生产出所需数量，便会遵循与任何其他合成药物相同的路径。
