Su Y, Wang X Q, Wu M, Tang Z Z, Kong L H, Wang Y L, Chen L M
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1987 Jul;9(4):251-4.
Detailed G-banded chromosome analysis was carried out on the bone marrow and/or PHA-stimulated peripheral blood cells from 17 SCLC patients (14 males and 3 females), who were diagnosed cytologically or pathologically or both. Twelve of them had no prior treatment and 16 had a heavy smoking history. High chromosome aberration rates were found in the bone marrow (31% for average structural aberration rate and 63% for numerical aberration rate) and peripheral blood cells (37% for average structural aberration rate and 49% for numerical aberration rate). The smoking index, as a whole, was positively correlated to the structural chromosome aberration rate, indicating that smoking is one of the most important environmental factors in causing chromosome aberrations. But some patients gave a high aberration rate dis-proportional to their smoking index, suggesting that genetically determined susceptibility to smoking or even other factors also play an important role. The structural chromosome aberrations in the bone marrow and peripheral blood cells were mainly clustered on chromosome 3 and chromosomes 1, 9 and 11, respectively. The aberration types were manifold and complicated. No consistent or specific aberration as del 3p14-23 for SCLC was found in this study.
对17例经细胞学或病理或两者确诊的小细胞肺癌患者（14例男性，3例女性）的骨髓和/或PHA刺激的外周血细胞进行了详细的G显带染色体分析。其中12例未曾接受过治疗，16例有重度吸烟史。在骨髓中发现高染色体畸变率（平均结构畸变率为31%，数目畸变率为63%），在外周血细胞中也发现高染色体畸变率（平均结构畸变率为37%，数目畸变率为49%）。总体而言，吸烟指数与染色体结构畸变率呈正相关，表明吸烟是导致染色体畸变的最重要环境因素之一。但有些患者的畸变率与其吸烟指数不成比例，提示遗传决定的对吸烟的易感性甚至其他因素也起重要作用。骨髓和外周血细胞中的染色体结构畸变主要分别聚集在3号染色体以及1、9和11号染色体上。畸变类型多样且复杂。本研究未发现小细胞肺癌中一致或特异的畸变，如3p14 - 23缺失。
