抗原生动物寄生虫隐孢子虫和弓形虫药物研发的最新进展。
Recent developments in drug discovery against the protozoal parasites Cryptosporidium and Toxoplasma.
作者信息
Chellan Prinessa, Sadler Peter J, Land Kirkwood M
机构信息
Department of Chemistry, University of Warwick, Coventry, Warwickshire CV4 7AL, UK.
Department of Biological Sciences, University of the Pacific, Stockton, CA 95211, United States.
出版信息
Bioorg Med Chem Lett. 2017 Apr 1;27(7):1491-1501. doi: 10.1016/j.bmcl.2017.01.046. Epub 2017 Jan 17.
Apicomplexan parasites cause some of the most devastating human diseases, including malaria, toxoplasmosis, and cryptosporidiosis. New drug discovery is imperative in light of increased resistance. In this digest article, we briefly explore some of the recent and promising developments in new drug discovery against two apicomplexan parasites, Cryptosporidium and Toxoplasma.
顶复门寄生虫引发了一些最具毁灭性的人类疾病，包括疟疾、弓形虫病和隐孢子虫病。鉴于耐药性增加，新药研发势在必行。在这篇综述文章中，我们简要探讨了针对两种顶复门寄生虫——隐孢子虫和弓形虫的新药研发方面一些近期且有前景的进展。
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