感染不同质粒组成的鼠疫耶尔森菌的小白鼠的免疫发生

Immunogenesis in White Mice Infected with Yersinia pestis with Different Plasmid Composition.

作者信息

Balakhonov S V, Vityazeva S A, Dubrovina V I, Starovoitova T P, Mukhturgin G B, Ivanova T A, Korytov K M, Kolesnikov S I

机构信息

Irkutsk Antiplague Research Institute of Siberia and Far East of Federal Service on Supervision in the Sphere of Consumers' Rights Protection and Human Welfare, Irkutsk, Russia.

Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russia.

出版信息

Bull Exp Biol Med. 2017 Feb;162(4):470-473. doi: 10.1007/s10517-017-3642-0. Epub 2017 Feb 27.

DOI:10.1007/s10517-017-3642-0

PMID:28243913

Abstract

Morphological changes in the immunocompetent organs of white mice with experimental plague infection manifested in activation of the immune response of different degree and pathological process of different severity that depended on the plasmid composition of Y. pestis. Widening of the T-dependent zones in the immune organs of white mice infected with isogenic strains of Y. pestis with different plasmid composition attests to activation of cellular immunity. Our findings allow considering Y. pestis subsp. altaica I-2948/3, Y. pestis subsp. pestis I-3479 and Y. pestis subsp. pestis I-3480 as promising candidates for vaccine strains.

摘要

实验性鼠疫感染的小白鼠免疫活性器官的形态学变化表现为不同程度的免疫反应激活和不同严重程度的病理过程，这取决于鼠疫耶尔森菌的质粒组成。用具有不同质粒组成的鼠疫耶尔森菌同基因菌株感染的小白鼠免疫器官中T细胞依赖区变宽，证明细胞免疫被激活。我们的研究结果使我们可以将阿尔泰鼠疫耶尔森菌亚种I-2948/3、鼠疫耶尔森菌亚种鼠疫I-3479和鼠疫耶尔森菌亚种鼠疫I-3480视为有前景的疫苗菌株候选者。