前列环素（PGI2）可导致大鼠脑细胞核中环磷酸腺苷（cAMP）水平迅速降低。

Prostacyclin (PGI2) induces rapid depletion of cyclic AMP levels in brain nuclei of rats.

作者信息

Schmid G, Bahner U, Palkovits M, Geiger H, Heidland A

机构信息

Medical Clinic of the University Department of Nephrology, Wuerzburg, FRG.

出版信息

Life Sci. 1987 Dec 7;41(23):2547-53. doi: 10.1016/0024-3205(87)90439-5.

DOI:10.1016/0024-3205(87)90439-5

PMID:2824960

Abstract

Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticular nucleus (A1 and C1 catecholaminergic cell groups) cAMP levels were depleted significantly, while in others, including the locus coeruleus and the periaqueductal central gray, cAMP levels did not show any alterations. Levels of cAMP were also depleted in some of the hypothalamic nuclei (periventricular, anterior hypothalamic, ventromedial), and in cerebral cortical areas. Lowered cAMP levels in brain areas might indicate lower cellular activity in cells participating in baroreceptor control mechanisms.

摘要

给大鼠静脉注射前列环素（100微克/千克）可导致收缩压在2分钟内下降。采用放射免疫分析法测定了15个脑区和神经核中的环磷酸腺苷（cAMP）浓度。在延髓下部的神经核，如孤束核和外侧网状核（A1和C1儿茶酚胺能细胞群），cAMP水平显著降低，而在其他区域，包括蓝斑和导水管周围中央灰质，cAMP水平未显示任何变化。在下丘脑的一些神经核（室周核、下丘脑前核、腹内侧核）以及大脑皮质区域，cAMP水平也降低。脑区中cAMP水平降低可能表明参与压力感受器控制机制的细胞的细胞活性较低。