Brown Jacqueline, Beckmann Michael
Mater HEALTH, Department of Obstetrics and Gynaecology, Mater Health Services, Raymond Terrace, South Brisbane, Queensland, Australia.
Aust N Z J Obstet Gynaecol. 2017 Feb;57(1):68-73. doi: 10.1111/ajo.12577.
The process of induction of labour (IOL) commonly involves cervical ripening, using mechanical or pharmacological methods. However, the optimum protocol of IOL remains undetermined.
To report the maternal, neonatal and process outcomes for women being induced with a balloon catheter or prostaglandin E2 gel (PGE2).
Matched retrospective cohort study of women requiring IOL at term with a modified Bishop's score (MBS) <7. Those who underwent cervical ripening with a double balloon catheter were matched 1:1 for parity, indication and MBS score to those using PGE2 gel. The primary outcome measure was mode of birth.
After exclusions, data from 427 women induced with a balloon catheter were able to be matched to 427 women induced with PGE2 gel. Compared to women receiving PGE2 gel, those induced using a balloon catheter were more likely to have an unassisted vaginal birth (50.4% vs 42.9%; P = 0.028), a lower mean estimated blood loss (420 vs 481 mL; P = 0.028), a reduction in fetal acidaemia (2.4% vs 8.8%; P = 0.003) and a greater likelihood experiencing vaginal delivery within 24 h (33.7% vs 25.8%; P = 0.011).
Similar to findings in randomised controlled trials and meta-analyses of IOL methods, we observed more unassisted vaginal births, less blood loss, decreased fetal acidaemia, and a greater likelihood of vaginal delivery within 24 h, with use of balloon catheter as compared to PGE2 vaginal gel.
引产(IOL)过程通常涉及使用机械或药物方法进行宫颈成熟。然而,引产的最佳方案仍未确定。
报告使用球囊导管或前列腺素E2凝胶(PGE2)引产的女性的母体、新生儿及过程结局。
对足月引产且改良Bishop评分(MBS)<7的女性进行匹配的回顾性队列研究。接受双球囊导管宫颈成熟的女性与使用PGE2凝胶的女性按1:1的比例匹配产次、引产指征和MBS评分。主要结局指标是分娩方式。
排除相关病例后,427例使用球囊导管引产的女性数据能够与427例使用PGE2凝胶引产的女性数据相匹配。与接受PGE2凝胶的女性相比,使用球囊导管引产的女性更有可能顺产(50.4%对42.9%;P = 0.028),平均估计失血量更低(420对481 mL;P = 0.028),胎儿酸中毒发生率降低(2.4%对8.8%;P = 0.003),且在24小时内阴道分娩的可能性更大(33.7%对25.8%;P = 0.011)。
与引产方法的随机对照试验和荟萃分析结果相似,我们观察到与PGE2阴道凝胶相比,使用球囊导管引产顺产更多、失血更少、胎儿酸中毒减少,且在24小时内阴道分娩的可能性更大。