Zhou Chengmao, Zhu Yu, Liu Zhen, Ruan Lin
Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China; Zhaoqing Medical College, Zhaoqing 526000, China.
Zhaoqing Medical College, Zhaoqing 526000, China.
Biomed Res Int. 2017;2017:6186832. doi: 10.1155/2017/6186832. Epub 2017 Feb 2.
. The aim of this meta-analysis is to evaluate the effects of dexmedetomidine on intraocular pressure (IOP) in patients with general anesthesia administered via intubation. . We searched randomized controlled trials (RCT) on the effects of intravenous injection of dexmedetomidine on IOP in patients with general anesthesia administered via intubation. . The meta-analysis study showed that (1) a statistically significant difference [WMD = -3.40 mmHg, 95% CI (-4.76, -2.04), < 0.00001] was found between IOP of the two groups. (2) The IOP of the dexmedetomidine group that was administrated succinylcholine was lower than that of placebo group which was administrated succinylcholine [WMD = -4.13 mmHg, 95% CI (-6.01, -2.25), < 0.0001]. (3) Compared with the IOP of patients in the placebo group, patients with intubation in the dexmedetomidine group maintained a lower IOP [WMD = -3.10 mmHg, 95% CI (-5.12, -1.07), = 0.003]. However, for incidences of bradycardia, the use of dexmedetomidine was higher than that of the placebo [RR = 0.23, 95% CI (0.07, 0.76), = 0.02]. . This meta-analysis showed that, in many cases, dexmedetomidine can lower the IOP of patients with general anesthesia administered by intubation.
本荟萃分析的目的是评估右美托咪定对经气管插管全身麻醉患者眼压（IOP）的影响。我们检索了关于静脉注射右美托咪定对经气管插管全身麻醉患者眼压影响的随机对照试验（RCT）。荟萃分析研究表明：（1）两组眼压之间存在统计学显著差异[加权均数差（WMD）=-3.40 mmHg，95%置信区间（CI）（-4.76，-2.04），P<0.00001]。（2）接受琥珀酰胆碱的右美托咪定组眼压低于接受琥珀酰胆碱的安慰剂组[WMD=-4.13 mmHg，95%CI（-6.01，-2.25），P<0.0001]。（3）与安慰剂组患者的眼压相比，右美托咪定组经气管插管患者的眼压维持在较低水平[WMD=-3.10 mmHg，95%CI（-5.12，-1.07），P=0.003]。然而，对于心动过缓的发生率，右美托咪定的使用高于安慰剂[相对危险度（RR）=0.23，95%CI（0.07，0.76），P=0.02]。本荟萃分析表明，在许多情况下，右美托咪定可降低经气管插管全身麻醉患者的眼压。
Zotero 插件
