Thomsen Birgitte Liang Chen, Herz Damian Marc, Siebner Hartwig Roman, Løkkegaard Annemette
Ugeskr Laeger. 2017 Mar 6;179(10).
Levodopa-induced dyskinesia (LID) represents a severe adverse effect of long-term treatment of Parkinson's disease with levodopa. Neuroimaging studies have contributed to our understanding of LID and may help to identify patients at risk of developing LID. Amantadine can be used for the treatment of LID, and novel drugs are under development. Deep brain stimulation of the subthalamic nucleus and globus pallidus internus alleviates LID, the former indirectly by reducing levodopa intake, the latter through direct effects. Repetitive transcranial magnetic stimulation has been shown to transiently improve LID.
左旋多巴诱导的异动症(LID)是帕金森病长期使用左旋多巴治疗产生的一种严重不良反应。神经影像学研究有助于我们对LID的理解,并可能有助于识别有发生LID风险的患者。金刚烷胺可用于治疗LID,新型药物也正在研发中。对丘脑底核和苍白球内侧部进行深部脑刺激可减轻LID,前者通过减少左旋多巴摄入量间接起作用,后者则通过直接作用起作用。重复经颅磁刺激已被证明可短暂改善LID。