64Cu-ATSM PET/CT对实体瘤的早期和延迟评估：半定量和计算机辅助分形几何分析的初步研究

Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT: a pilot study on semiquantitative and computer-aided fractal geometry analysis.

作者信息

Lopci Egesta, Grizzi Fabio, Russo Carlo, Toschi Luca, Grassi Ilaria, Cicoria Gianfranco, Lodi Filippo, Mattioli Sandro, Fanti Stefano

机构信息

aResearch Doctorate Course in Specialized Medical Sciences, Alma Mater Studiorum - University of Bologna bPET Unit cDivision of Thoracic Surgery, University Hospital S. Orsola-Malpighi, Bologna dDepartment of Nuclear Medicine eDepartment of Inflammation and Immunology fDepartment of Medical Oncology, Humanitas Clinical and Research Hospital, Rozzano gMichele Rodriguez Foundation, Milan, Italy.

出版信息

Nucl Med Commun. 2017 Apr;38(4):340-346. doi: 10.1097/MNM.0000000000000656.

DOI:10.1097/MNM.0000000000000656

PMID:28263239

Abstract

OBJECTIVE

The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses.

PATIENTS AND METHODS

Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension.

RESULTS

All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05).

CONCLUSION

Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.

摘要

目的

本研究旨在通过比较半定量分析和计算机辅助分形几何分析，对一小群患者进行铜-64双乙酰双N4-甲基硫代半卡巴腙（Cu-ATSM）PET/CT早期和延迟采集的情况进行分析。

患者与方法

对5例癌症患者进行了Cu-ATSM PET/CT检查，其中包括非小细胞肺癌和头颈癌患者。参与者根据体重静脉注射Cu-ATSM，并于60分钟（早期）和16小时（延迟）后在PET/CT混合成像仪上进行成像。重建后的图像在先进的工作站上进行可视化处理，以确定半定量参数：最大标准化摄取值（SUV）max、SUV与肌肉比值、平均SUV、缺氧体积（HV）和缺氧负荷（HB=HV×SUVmean）。使用专门的计算机程序对从两次扫描中获取的DICOM数据进行分析，以确定平均强度值、标准差、相对离散度、三维直方图分形维数和三维分形维数。

结果

在早期评估时，所有肿瘤病灶均显示Cu-ATSM摄取增加，SUV与肌肉比值中位数为4.42（范围：1.58 - 5.62），SUVmax中位数为5.3（范围：1.9 - 7.3），SUVmean中位数为2.8（范围：1.5 - 3.9），HV中位数为41.6 cm（范围：2.8 - 453.7），HB中位数为161.5 cm（范围：4.4 - 1112.5）。1小时时获得的所有半定量数据与延迟成像时获得的参数一致（P>0.05）。仅在肌肉的SUVmax方面发现了边缘性统计学显著差异（P=0.045）。对DICOM图像的分形几何分析表明，早期成像时的所有参数与延迟采集时相比均无统计学显著差异（P>0.05）。