Univ Lyon, Université Claude Bernard Lyon 1, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS, CNRS UMR 5246), F-69622 Villeurbanne, France.
J Org Chem. 2017 Mar 17;82(6):3311-3316. doi: 10.1021/acs.joc.7b00085. Epub 2017 Mar 6.
4-Fluoropyrazoles are accessible in a single step from readily available aldehyde-derived N-alkylhydrazones through double C-H fluoroalkylation with tribromofluoromethane (CBrF). RuCl(PPh) has been proven to be the most efficient catalyst for this transformation when compared to a range of other Cu-, Pd-, or Fe-based catalyst systems.
4-氟吡唑可通过二溴三氟甲烷（CBrF）与易得的醛衍生的 N-烷基腙一步双 C-H 氟烷基化得到。与一系列其他基于 Cu、Pd 或 Fe 的催化剂体系相比，RuCl(PPh) 已被证明是该转化最有效的催化剂。
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