在自愿性前肢运动和停顿期间，运动皮层和纹状体神经元中持续的膜电位波动。

Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses.

作者信息

Nonomura Satoshi, Fujiwara-Tsukamoto Yoko, Kajihara Takafumi, Fujiyama Fumino, Isomura Yoshikazu

机构信息

Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan.

Brain Science Institute/Graduate School of Brain Sciences, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan; Laboratory of Neural Circuitry, Graduate School of Brain Science, Doshisha University, 1-3 Tatara Miyakodai, Kyotanabe, Kyoto 610-0394, Japan; CREST, Japan Science and Technology Agency, 7 Gobancho, Chiyodaku, Tokyo 102-0076, Japan; Faculty of Human Life Studies, Department of Food and Nutrition, Hagoromo University of International Studies, 1-89-1 Hamadera Minamimachi, Nishiku, Sakai, Osaka 592-8344, Japan.

出版信息

Neurosci Res. 2017 Jul;120:53-59. doi: 10.1016/j.neures.2017.03.002. Epub 2017 Mar 4.

DOI:10.1016/j.neures.2017.03.002

PMID:28267578

Abstract

Theoretical simulations suggest that spike rate is regulated by varying both membrane potential and its fluctuation. We investigated whether membrane potential fluctuation functionally changes in motor cortex and striatum neurons during discrete forelimb movements and pauses, or at rest, using whole-cell recording in task-performing rats. Membrane potential fluctuation was diminished by task performance, but maintained overall in the alpha/beta and gamma bands during forelimb movements and pauses. By contrast, membrane potential itself was correlated with spike rate in task-related neurons. Thus, membrane potential, but not its fluctuation, is a critical determinant of execution and pausing of discrete movements.

摘要

理论模拟表明，放电频率受膜电位及其波动变化的调节。我们利用在执行任务的大鼠中进行的全细胞记录，研究了在离散前肢运动、停顿或静止期间，运动皮层和纹状体神经元的膜电位波动在功能上是否发生变化。任务执行会使膜电位波动减小，但在前肢运动和停顿期间，α/β和γ频段的膜电位波动总体上得以维持。相比之下，膜电位本身与任务相关神经元的放电频率相关。因此，膜电位而非其波动，是离散运动执行和停顿的关键决定因素。