Pinheiro Gustavo R, Soares Guilherme S, Costa Andre Luis, Lotufo Roberto A, Rittner Leticia
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:1120-1123. doi: 10.1109/EMBC.2016.7590900.
This work proposes a novel approach to the analysis of Diffusion Tensor Imaging (DTI) by applying the mathematical concept of divergence, used in vector analysis. This is achieved by choosing an arbitrary direction of analysis and using this direction to transform the diffusion tensor field into an oriented vector field. The method was inspired by the idea of imposing a liquid flow inside the biological tissues, oriented in the direction of analysis, and watching the direction it would be expected to take as it flows through the paths created by the fibers. The experiments were conducted for the particular case of the analysis of the corpus callosum, using real DTI from several subjects. Results showed that the divergence map allows extraction of useful information about the spatial organization of the corpus callosum, providing a way to determine a reference plane that could be used, for example, in studies involving intersubject comparison.
这项工作提出了一种通过应用向量分析中使用的散度这一数学概念来分析扩散张量成像（DTI）的新方法。这是通过选择一个任意的分析方向并使用该方向将扩散张量场转换为一个定向向量场来实现的。该方法的灵感来自于在生物组织内部施加沿分析方向流动的液体流，并观察其在通过纤维形成的路径流动时预期会采取的方向这一想法。针对胼胝体分析的特定情况进行了实验，使用了来自多个受试者的真实DTI数据。结果表明，散度图能够提取有关胼胝体空间组织的有用信息，提供了一种确定参考平面的方法，例如，可用于涉及受试者间比较的研究。
