杜兴氏肌肉营养不良犬模型中的局部MRI与组织学图像相关性
Localized MRI and histological image correlation in a canine model of duchenne muscular dystrophy.
作者信息
Eresen A, McConnell S, Birch S M, Griffin J F, Kornegay J N, Ji J X
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:4083-4086. doi: 10.1109/EMBC.2016.7591624.
Duchenne Muscular Dystrophy (DMD) is a fatal X-linked disorder. Therapeutic assessments currently require muscle biopsy to ascertain information about the status of disease progression. MRI shows potential to be used in place of muscle biopsy for therapeutic assessments. In this work, localized histological data and various MRI parameters were correlated in a canine model of DMD. The results indicate several MRI parameters may be useful as biomarkers of disease progression.
杜兴氏肌肉营养不良症（DMD）是一种致命的X连锁疾病。目前的治疗评估需要进行肌肉活检以确定疾病进展状况的信息。磁共振成像（MRI）显示出可用于替代肌肉活检进行治疗评估的潜力。在这项研究中，在DMD犬模型中对局部组织学数据和各种MRI参数进行了相关性分析。结果表明，几个MRI参数可能作为疾病进展的生物标志物有用。
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