嵌合抗原受体T细胞（CAR T）设计基础及实体瘤免疫治疗中的挑战——以卵巢癌为例
The basics of CAR T design and challenges in immunotherapy of solid tumors - Ovarian cancer as a model.
作者信息
Xu Xuequn, Qiu Jin, Sun Yi
机构信息
a Department of Obstetrics and Gynecology , Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University , Shanghai , China.
出版信息
Hum Vaccin Immunother. 2017 Jul 3;13(7):1548-1555. doi: 10.1080/21645515.2017.1291473. Epub 2017 Mar 8.
Abstract
Chimeric antigen receptor T cells are T cells genetically engineered with CAR constructs which mainly contain scFV and TCR zeta chain. With promising development in blood cancers, CAR T trials are also applied in solid cancers. However, the treatment effect in solid cancers is lower than expected. This review summarizes difference of CAR T applications in solid and blood cancers. Future challenges of CAR T cell treatment in solid cancer are also discussed using ovarian cancer as an example.
摘要
嵌合抗原受体T细胞是经基因工程改造，带有主要包含单链抗体片段（scFV）和T细胞受体ζ链的嵌合抗原受体（CAR）构建体的T细胞。随着在血液癌症治疗方面取得了令人期待的进展，CAR-T试验也被应用于实体癌症治疗。然而，在实体癌症中的治疗效果低于预期。本综述总结了CAR-T在实体癌症和血液癌症应用中的差异。还以卵巢癌为例讨论了CAR-T细胞治疗实体癌症未来面临的挑战。
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